Evidence map›Paper›PMID 29609022›Full record

ReviewFree radical biology & medicine2018

NADPH-dependent and -independent disulfide reductase systems.

Colin G Miller, Arne Holmgren, Elias S J Arnér, Edward E Schmidt

Abstract readReview
In one paragraph

Review in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Disulfide-Bridged Ru Complex-Mediated Photo-Disulfidptosis for Colorectal Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Disulfidptosis in tumor progression.Cell death discovery · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Colin G MillerDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717, USA; Department of Microbiology & Immunology, Montana State University, Bozeman, MT 59717, USA.
Arne HolmgrenDivision of Biochemistry, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden.
Elias S J ArnérDivision of Biochemistry, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden.
Edward E SchmidtDepartment of Microbiology & Immunology, Montana State University, Bozeman, MT 59717, USA. Electronic address: eschmidt@montana.edu.

Funding

Mechanisms of arsenic detoxification by the human microbiomeR01CA215784 · NCI · MONTANA STATE UNIVERSITY - BOZEMAN · PI Seth T Walk, Qian Wang · 2017 to 2026
$2.7M
Impact of hepatocyte lineage life history dynamics on liver homeostasis in the agR01AG040020 · NIA · MONTANA STATE UNIVERSITY - BOZEMAN · PI GEDEON, TOMAS, SCHMIDT, EDWARD E · 2011 to 2015
$1.5M
Redox regulation in the hepatostatR21AG055022 · NIA · MONTANA STATE UNIVERSITY - BOZEMAN · PI ARNER, ELIAS S.J., NAGY, PETER · 2016 to 2017
$382k
NCI NIH HHS R01 CA215784NIA NIH HHS R01 AG040020NIA NIH HHS R21 AG055022
6 · The paper itself

Abstract

Over the past seven decades, research on autotrophic and heterotrophic model organisms has defined how the flow of electrons ("reducing power") from high-energy inorganic sources, through biological systems, to low-energy inorganic products like water, powers all of Life's processes. Universally, an initial major biological recipient of these electrons is nicotinamide adenine dinucleotide-phosphate, which thereby transits from an oxidized state (NADP

Indexed as

AnimalsHumansNADH, NADPH OxidoreductasesNADPOxidation-ReductionRibonucleotide Reductasesdisulfide reductase (NADH)NADH, NADPH OxidoreductasesNADPRibonucleotide ReductasesCysteineGlutathione reductaseMethionine cycleNADPHRibonucleotide reductaseSulfur amino acidThioredoxin reductaseTranssulfuration

Identifiers

PMID29609022
PMCPMC6165701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.