ReviewNeuroscience and biobehavioral reviews2018
Dynamic coupling between the central and autonomic nervous systems during sleep: A review.
Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
94 citing papers in PubMed.
- Cardiovascular Responses to Natural and Auditory Evoked Slow Waves Predict Post-Sleep Cardiac Function.Journal of sleep research · 2026Trial
- Wireless wearable sensors can facilitate rapid detection of sleep apnea in hospitalized stroke patients.Sleep · 2024Trial
- Effects of sleep fragmentation and partial sleep restriction on heart rate variability during night.Scientific reports · 2023Trial
- Effects of Ultrasound-Guided Stellate Ganglion Block on Postoperative Quality of Recovery in Patients Undergoing Breast Cancer Surgery: A Randomized Controlled Clinical Trial.Journal of healthcare engineering · 2022Trial
- Reducing bedtime physiological arousal levels using immersive audio-visual respiratory bio-feedback: a pilot study in women with insomnia symptoms.Journal of behavioral medicine · 2019Trial
- Strengthening sleep-autonomic interaction via acoustic enhancement of slow oscillations.Sleep · 2019Trial
- Delta-9-Tetrahydrocannabinol (THC) Before Bedtime: Feasibility and Mechanistic Pilot Study on Sleep and Cardiac Autonomic Activity.Journal of sleep research · 2026Article
- Tone-Evoked Sleep Electroencephalographic Slow Oscillations as a Function of Peripheral Rhythms: New Insights Into the Brain-Heart Integration.Journal of sleep research · 2026Article
- Article
- The interactive effect of long nighttime sleep and daytime napping on QTc prolongation in hypertensive adults.BMC cardiovascular disorders · 2026Article
- Nocturnal heart rate variability in Parkinson's disease: associations with autonomic dysfunction, cognitive function, and mood symptoms.Clinical parkinsonism & related disorders · 2026Article
- Modulation of neurofluid fluctuation frequency by baseline carbon dioxide in awake humans: the role of the autonomic nervous system.Frontiers in physiology · 2026Article
- MRI methods for the study of central nervous system involvement in autonomic function.Frontiers in network physiology · 2026Review
- Cardiovascular Activity Predominantly Modulates Brain Dynamics in Non-REM Sleep Transitions.Annals of the New York Academy of Sciences · 2026Article
- Continuous bidirectional coupling of heart rate variability and emotions in dyad speaker-listener dynamics reveals unique interpersonal synchronization.Frontiers in systems neuroscience · 2026Article
- Simultaneous EEG-PET-MRI identifies temporally coupled and spatially structured brain dynamics across wakefulness and NREM sleep.Nature communications · 2025Article
- [Evaluation method and system for aging effects of autonomic nervous system based on cross-wavelet transform cardiopulmonary coupling].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Dynamic brain-heart interaction in sleep characterized by variational phase-amplitude coupling framework.Communications biology · 2025Article
- BrainFusion: a Low-Code, Reproducible, and Deployable Software Framework for Multimodal Brain‒Computer Interface and Brain‒Body Interaction Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Autonomic physiological coupling of the global fMRI signal.Nature neuroscience · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Sleep is characterized by coordinated cortical and cardiac oscillations reflecting communication between the central (CNS) and autonomic (ANS) nervous systems. Here, we review fluctuations in ANS activity in association with CNS-defined sleep stages and cycles, and with phasic cortical events during sleep (e.g., arousals, K-complexes). Recent novel analytic methods reveal a dynamic organization of integrated physiological networks during sleep and indicate how multiple factors (e.g., sleep structure, age, sleep disorders) affect "CNS-ANS coupling". However, these data are mostly correlational and there is a lack of clarity of the underlying physiology, making it challenging to interpret causality and direction of coupling. Experimental manipulations (e.g., evoking K-complexes or arousals) provide information on the precise temporal sequence of cortical-cardiac activity, and are useful for investigating physiological pathways underlying CNS-ANS coupling. With the emergence of new analytical approaches and a renewed interest in ANS and CNS communication during sleep, future work may reveal novel insights into sleep and cardiovascular interactions during health and disease, in which coupling could be adversely impacted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.