Evidence map›Paper›PMID 29608868›Full record

ArticleJournal of dental research2018

Biomechanics of Immediate Postextraction Implant Osseointegration.

X Yuan, X Pei, Y Zhao, Z Li, C H Chen, U S Tulu, B Liu, L A Van Brunt, J B Brunski, J A Helms

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Relationship Between Primary/Mechanical and Secondary/Biological Implant Stability.The International journal of oral & maxillofacial implants
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Guidance and rationale for the immediate implant placement in the maxillary molar.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Bioactivating a bone substitute accelerates graft incorporation in a murine model of vertical ridge augmentation.Dental materials : official publication of the Academy of Dental Materials · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

X Yuan1 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA.ORCID 0000-0002-8063-9431
X Pei1 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA.
Y Zhao1 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA.
Z Li1 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA.
C H Chen1 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA.
U S Tulu1 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA.
B Liu6 Ankasa Regenerative Therapeutics, South San Francisco, CA, USA.
L A Van Brunt1 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA.
J B Brunski1 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA.
J A Helms1 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA.ORCID 0000-0002-0463-396X
Stanford Medicine · USNkarta Therapeutics (United States) · USChang Gung University · TWSichuan University · CNTianjin Medical University General Hospital · CN

Funding

Mechanobiology at Healing Bone-Implant InterfacesR01DE024000 · NIDCR · STANFORD UNIVERSITY · PI BRUNSKI, JOHN BEYER, HELMS, JILL A · 2014 to 2018
$3.4M
NIDCR NIH HHS R01 DE024000
6 · The paper itself

Abstract

The aim of this study was to gain insights into the biology and mechanics of immediate postextraction implant osseointegration. To mimic clinical practice, murine first molar extraction was followed by osteotomy site preparation, specifically in the palatal root socket. The osteotomy was positioned such that it removed periodontal ligament (PDL) only on the palatal aspect of the socket, leaving the buccal aspect undisturbed. This strategy created 2 distinct peri-implant environments: on the palatal aspect, the implant was in direct contact with bone, while on the buccal aspect, a PDL-filled gap existed between the implant and bone. Finite element modeling showed high strains on the palatal aspect, where bone was compressed by the implant. Osteocyte death and bone resorption predominated on the palatal aspect, leading to the loss of peri-implant bone. On the buccal aspect, where finite element modeling revealed low strains, there was minimal osteocyte death and robust peri-implant bone formation. Initially, the buccal aspect was filled with PDL remnants, which we found directly provided Wnt-responsive cells that were responsible for new bone formation and osseointegration. On the palatal aspect, which was devoid of PDL and Wnt-responsive cells, adding exogenous liposomal WNT3A created an osteogenic environment for rapid peri-implant bone formation. Thus, we conclude that low strain and high Wnt signaling favor osseointegration of immediate postextraction implants. The PDL harbors Wnt-responsive cells that are inherently osteogenic, and if the PDL tissue is healthy, it is reasonable to preserve this tissue during immediate implant placement.

Indexed as

Biomechanical PhenomenaDental Implants, Single-ToothImmediate Dental Implant LoadingTooth ExtractionAnimalsBone-Implant InterfaceFinite Element AnalysisIn Situ Nick-End LabelingMaxillary OsteotomyMiceModels, AnimalMolarOsseointegrationOsteogenesisPeriodontal LigamentTooth Socketcell lineagedental implantationosteogenicperiodontal ligamenttooth extractionWnt3 protein

Identifiers

PMID29608868
PMCPMC6055256
OpenAlexW2796446112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.