ArticleSchizophrenia bulletin2018
Negative Schizotypy and Altered Functional Connectivity During Facial Emotion Processing.
Article in Schizophrenia bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Neural association between mental symptoms and facial emotion recognition in deficit schizophrenia: an fNIRS study.BMC psychiatry · 2025Article
- Facial Emotion Recognition and its Associations With Psychological Well-Being Across Four Schizotypal Dimensions: a Cross-Sectional Study.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Cell-type specific reductions in interneuron gene expression within the cingulate gyrus of schizophrenia and bipolar disorder subjects.Schizophrenia (Heidelberg, Germany) · 2025Article
- Amygdala Function, Blood Flow, and Functional Connectivity in Nonclinical Schizotypy.Schizophrenia bulletin · 2025Article
- Negative Schizotypy Associated With Weaker Intersubject Correlation in Dynamic Functional Connectivity During Empathic Accuracy Task.Schizophrenia bulletin · 2025Article
- Neuropsychology and Neurobiology of Negative Schizotypy: A Selective Review.Biological psychiatry global open science · 2024Review
- Cognitive Processes and Resting-State Functional Neuroimaging Findings in High Schizotypal Individuals and Schizotypal Personality Disorder Patients: A Systematic Review.Brain sciences · 2023Review
- Association between fractional amplitude of low-frequency fluctuation (fALFF) and facial emotion recognition ability in first-episode schizophrenia patients: a fMRI study.Scientific reports · 2022Article
- High Predictive Accuracy of Negative Schizotypy With Acoustic Measures.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Nonclinical psychotic-like experiences and schizotypy dimensions: Associations with hippocampal subfield and amygdala volumes.Human brain mapping · 2021Article
- High Schizotypy Predicts Emotion Recognition Independently of Negative Affect.Frontiers in psychiatry · 2021Article
- Processing of Affective Pictures: A Study Based on Functional Connectivity Network in the Cerebral Cortex.Computational intelligence and neuroscience · 2021Article
- Implicit emotion regulation deficits in individuals with high schizotypal traits: an ERP study.Scientific reports · 2020Article
- Analyzing Brain Connectivity in the Mutual Regulation of Emotion-Movement Using Bidirectional Granger Causality.Frontiers in neuroscience · 2020Article
- Classification of social anhedonia using temporal and spatial network features from a social cognition fMRI task.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Impairment in facial emotion perception is an important domain of social cognition deficits in schizophrenia. Although impaired facial emotion perception has been found in individuals with negative schizotypy (NS), little is known about the corresponding change in brain functional connectivity. Methods: Sixty-four participants were classified into a high NS group (n = 34) and a low NS group (n = 30) based on their total scores on the Chapman scales for physical and social anhedonia. All participants undertook a facial emotion discrimination functional imaging task that consisted of four emotional valences (angry, fear, happy, and neutral). For univariate analysis, the signal change at the bilateral amygdala was compared for each emotional contrast using SPSS (P < .05). For the functional connectivity analysis, we calculated the beta-series functional connectivity of the bilateral amygdala with the medial prefrontal cortex (mPFC) and compared the group differences in SPM12 (P < .05, small volume family-wise error correction). Results: No significant differences were found between the high and low NS groups in accuracy and reaction time in the facial emotion discrimination task. The high NS group showed reduced brain activations at the amygdala under fearful and neutral conditions. Reduced functional connectivity between the amygdala and the mPFC/dorsal anterior cingulate cortex under the happy and fearful conditions in the high NS group was also found. Conclusions: Our findings suggest that the individuals with high NS showed altered brain activity and functional connectivity at the amygdala during facial emotion processing and provide new evidence for understanding social cognition deficits in at-risk individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.