ArticleCerebral cortex (New York, N.Y. : 1991)2019
Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- GABA, Glutamate and Neural Activity: A Systematic Review With Meta-Analysis of MultimodalFrontiers in psychiatry · 2021Pooled it
- Subacute changes in brain functional network connectivity after nocturnal sodium oxybate intake are associated with anterior cingulate GABA.Cerebral cortex (New York, N.Y. : 1991) · 2023Trial
- Greater Somatosensory Afference With Acupuncture Increases Primary Somatosensory Connectivity and Alleviates Fibromyalgia Pain via Insular γ-Aminobutyric Acid: A Randomized Neuroimaging Trial.Arthritis & rheumatology (Hoboken, N.J.) · 2021Trial
- Mapping the functional connectome between grey matter and white matter.Communications biology · 2026Article
- Linking GABAergic and Dopaminergic Neurotransmission: Effects on Neural Activity During Human Speech Control.Human brain mapping · 2026Article
- Competitive interactions shape mammalian brain network dynamics and computation.Nature neuroscience · 2026Article
- Redox therapy for neuropsychiatric disorders: Molecular mechanisms and biomarker development.Science advances · 2026Review
- Real-time neurofeedback, its neurotransmitter underpinnings, and therapeutic effects: study protocol for a randomized controlled trial in individuals at clinical high risk.BMC psychiatry · 2025Article
- Epigenetic Landscapes of Methamphetamine Addiction: Unravelling the Diagnostic Potential of Gene Methylation.Addiction biology · 2025Article
- Heterogeneity of brain functional connectivity, transcriptome, and neurotransmitter profiles in major depressive disorder.Psychological medicine · 2025Article
- Intranasal Insulin Increases Brain Glutathione and Enhances Antioxidant Capacity in Healthy Participants but Not in Those With Early Psychotic Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Altered cortical thickness associated with psychotic symptoms and cognitive profiles in involuntarily hospitalized, first-episode, drug-naive patients with schizophrenia.Frontiers in psychiatry · 2025Article
- Rebalance the Inhibitory System in the Elderly Brain: Influence of Balance Learning on GABAergic Inhibition and Functional Connectivity.Human brain mapping · 2024Article
- Glutamate concentration of medial prefrontal cortex is inversely associated with addictive behaviors: a translational study.Translational psychiatry · 2024Article
- GABAergic inhibition in human hMT+ predicts visuo-spatial intelligence mediated through the frontal cortex.eLife · 2024Article
- Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types.Nature communications · 2024Article
- Neural response to stress differs by sex in young adulthood.Psychiatry research. Neuroimaging · 2023Article
- Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder.Translational psychiatry · 2023Review
- Chronic cannabis use alters dACC-striatal glutamatergic balance.Pharmacology, biochemistry, and behavior · 2023Article
- Association of default-mode network neurotransmitters and inter-network functional connectivity in first episode psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
Coordinated activity within and differential activity between large-scale neuronal networks such as the default mode network (DMN) and the control network (CN) is a critical feature of brain organization. The CN usually exhibits activations in response to cognitive tasks while the DMN shows deactivations; in addition, activity between the two networks is anti-correlated at rest. To address this issue, we used functional MRI to measure whole-brain BOLD signal during resting-state and task-evoked conditions, and MR spectroscopy (MRS) to quantify GABA and glutamate concentrations, in nodes within the DMN and CN (MPFC and DLPFC, respectively) in 19 healthy individuals at 3 Tesla. We found that GABA concentrations in the MPFC were significantly associated with DMN deactivation during a working memory task and with anti-correlation between DMN and CN at rest and during task performance, while GABA concentrations in the DLPFC weakly modulated DMN-CN anti-correlation in the opposite direction. Highlighting specificity, glutamate played a less significant role related to brain activity. These findings indicate that GABA in the MPFC is potentially involved in orchestrating between-network brain activity at rest and during task performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.