ArticlePloS one2018
TGA2 signaling in response to reactive electrophile species is not dependent on cysteine modification of TGA2.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Molecular Mechanisms and Network Integration of Oxylipin Signaling in Plant Abiotic Stress Tolerance.International journal of molecular sciences · 2026Review
- A CW-type zinc finger protein is involved in RES-oxylipin signaling and the response to abiotic stress inFrontiers in plant science · 2025Article
- OPDA/dn-OPDA actions: biosynthesis, metabolism, and signaling.Plant cell reports · 2024Review
- Oxylipins and Reactive Carbonyls as Regulators of the Plant Redox and Reactive Oxygen Species Network under Stress.Antioxidants (Basel, Switzerland) · 2023Review
- JAZ is essential for ligand specificity of the COI1/JAZ co-receptor.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- OPDAylation of Thiols of the Redox Regulatory Network In Vitro.Antioxidants (Basel, Switzerland) · 2022Article
- TGA transcription factors-Structural characteristics as basis for functional variability.Frontiers in plant science · 2022Review
- TGA class II transcription factors are essential to restrict oxidative stress in response to UV-B stress in Arabidopsis.Journal of experimental botany · 2021Article
- Photosynthetic signalling during high light stress and recovery: targets and dynamics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- The Chloroplast Reactive Oxygen Species-Redox System in Plant Immunity and Disease.Frontiers in plant science · 2020Review
- Nitric oxide molecular targets: reprogramming plant development upon stress.Journal of experimental botany · 2019Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive electrophile species (RES), including prostaglandins, phytoprostanes and 12-oxo phytodienoic acid (OPDA), activate detoxification responses in plants and animals. However, the pathways leading to the activation of defense reactions related to abiotic or biotic stress as a function of RES formation, accumulation or treatment are poorly understood in plants. Here, the thiol-modification of proteins, including the RES-activated basic region/leucine zipper transcription factor TGA2, was studied. TGA2 contains a single cysteine residue (Cys186) that was covalently modified by reactive cyclopentenones but not required for induction of detoxification genes in response to OPDA or prostaglandin A1. Activation of the glutathione-S-transferase 6 (GST6) promoter was responsive to cyclopentenones but not to unreactive cyclopentanones, including jasmonic acid suggesting that thiol reactivity of RES is important to activate the TGA2-dependent signaling pathway resulting in GST6 activation We show that RES modify thiols in numerous proteins in vivo, however, thiol reactivity alone appears not to be sufficient for biological activity as demonstrated by the failure of several membrane permeable thiol reactive reagents to activate the GST6 promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.