Evidence map›Paper›PMID 29608398›Full record

ArticleSLAS discovery : advancing life sciences R & D2018

A High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry.

Tione Buranda, Catherine Gineste, Yang Wu, Virginie Bondu, Dominique Perez, Kaylin R Lake, Bruce S Edwards, Larry A Sklar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SLAS discovery : advancing life sciences R & D, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  5. Review
  6. Applications of Flow Cytometry in Drug Discovery and Translational Research.International journal of molecular sciences · 2024
    Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tione Buranda1 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA, and in revised form Feb 15, 2018. Accepted for publication Mar 1, 2018.
Catherine Gineste3 University of New Mexico Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Yang Wu1 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA, and in revised form Feb 15, 2018. Accepted for publication Mar 1, 2018.
Virginie Bondu1 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA, and in revised form Feb 15, 2018. Accepted for publication Mar 1, 2018.
Dominique Perez1 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA, and in revised form Feb 15, 2018. Accepted for publication Mar 1, 2018.
Kaylin R Lake5 Department of Biochemistry, University of New Mexico, Albuquerque, NM, USA.
Bruce S Edwards1 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA, and in revised form Feb 15, 2018. Accepted for publication Mar 1, 2018.
Larry A Sklar1 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA, and in revised form Feb 15, 2018. Accepted for publication Mar 1, 2018.
University of New Mexico · USNew Mexico Cancer Center · US

Funding

Yeast Biology ConsortiumU54MH084690 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI TEGOS, GEORGE P · 2008 to 2013
$14.4M
Development of HTS Assays for Inhibitors of Viral-Cell InteractionsR21NS066429 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BURANDA, TIONE · 2010 to 2010
$151k
NIMH NIH HHS U54 MH084690NINDS NIH HHS R21 NS066429
6 · The paper itself

Abstract

Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which infects more than 200,000 people worldwide. Sin Nombre virus (SNV) and Andes virus (ANDV) cause the most severe form of HCPS, with case fatality ratios of 30%-40%. There are no specific therapies or vaccines for SNV. Using high-throughput flow cytometry, we screened the Prestwick Chemical Library for small-molecule inhibitors of the binding interaction between UV-inactivated and fluorescently labeled SNV

Indexed as

Flow CytometryHigh-Throughput Screening AssaysAnimalsAntiviral AgentsBiomarkersCell SurvivalChlorocebus aethiopsDose-Response Relationship, DrugHantavirus InfectionsHumansModels, BiologicalOrthohantavirusReproducibility of ResultsVero CellsVirus InternalizationAntiviral AgentsBiomarkerscyclic AMPdrug discoveryflow cytometryG proteinhantavirushigh-throughput screenintegrin activationmechanotransductionPAC-1PSI domainRap1

Identifiers

PMID29608398
PMCPMC6469676
OpenAlexW2796221051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.