Evidence map›Paper›PMID 29608257›Full record

SynthesisCancer medicine2018

Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses.

Jodie N Painter, Tracy A O'Mara, Andrew P Morris, Timothy H T Cheng, Maggie Gorman, Lynn Martin, Shirley Hodson, Angela Jones, Nicholas G Martin, Scott Gordon and 66 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

76 authors at 20 institutions in 8 countries.

Jodie N PainterDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0002-4992-2458
Tracy A O'MaraDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Andrew P MorrisWellcome Trust for Human Genetics, University of Oxford, Oxford, UK.
Timothy H T ChengWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Maggie GormanWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Lynn MartinWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Shirley HodsonDepartment of Clinical Genetics, St George's, University of London, London, UK.
Angela JonesWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Nicholas G MartinDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Scott GordonDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Anjali K HendersInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
John AttiaHunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
Mark McEvoyCentre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
Elizabeth G HollidayHunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
Rodney J ScottDivision of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia.
Penelope M WebbQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Peter A FaschingDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000-0003-4885-8471
Matthias W BeckmannDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Arif B EkiciInstitute of Human Genetics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Alexander HeinDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Matthias RübnerDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-9458-0282
Matthias DürstDepartment of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
Peter HillemannsGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Ingo RunnebaumDepartment of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
Diether LambrechtsVIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID 0000-0002-2402-4029
Frederic AmantDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.
Daniela AnnibaliDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.
Jeroen DepreeuwLaboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium.
Adriaan VandersticheleDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.
Ellen L GoodeDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-9094-8326
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Sean C DowdyDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mayo Clinic, Rochester, Minnesota.
Stacey J WinhamDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Jone TrovikCentre for Cancerbiomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Erling HoivikCentre for Cancerbiomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Henrica M J WernerCentre for Cancerbiomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Camilla KrakstadCentre for Cancerbiomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Katie AshtonHunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
Geoffrey OttonSchool of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
Tony ProiettoSchool of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
Emma ThamDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Miriam MintsDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Shahana AhmedDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Catherine S HealeyDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Mitul ShahDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Paul D P PharoahDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Alison M DunningDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Joe DennisDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Manjeet K BollaDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Kyriaki MichailidouDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Qin WangDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Jonathan P TyrerDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Julian PetoDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Barbara BurwinkelDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Alfons MeindlDivision of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
Hiltrud BrauchGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Vessela N KristensenDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.
Angela CoxDepartment of Oncology and Metabolism, Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield, Sheffield, UK.
Krina T ZondervanDepartment of Obstetrics & Gynaecology, Endometriosis CaRe Centre, Nuffield, University of Oxford, Oxford, UK.
Dale R NyholtDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Stuart MacGregorDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Grant W MontgomeryDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Ian TomlinsonWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Douglas F EastonDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Deborah J ThompsonDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Amanda B SpurdleDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
University of Cambridge · GBQIMR Berghofer Medical Research Institute · AUCentre for Human Genetics · GBKarolinska Institutet · SEHaukeland University Hospital · NOJohn Hunter Hospital · AUUniversitätsklinikum Erlangen · DEGerman Cancer Research Center · DEKU Leuven · BEMayo Clinic · USUniversity of Newcastle Australia · AUJena University Hospital · DEMayo Clinic in Florida · USMedizinische Hochschule Hannover · DEThe University of Melbourne · AUThe University of Queensland · AUCenter for Human Genetics · USInstitute of Cancer Research · GBLondon School of Hygiene & Tropical Medicine · GBOslo University Hospital · NO

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI ELLEN L. GOODE · 2009 to 2026
$37.0M
Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Ovarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2M
A genome-wide association study for breast cancer in BRCA1 mutation carriersR01CA128978 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2008 to 2012
$4.8M
Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer EtiologyR01CA122443 · NCI · MAYO CLINIC ROCHESTER · PI GOODE, ELLEN L. · 2007 to 2012
$2.7M
Cancer Research UK 10118Cancer Research UK 10119Cancer Research UK 16459Cancer Research UK 16561Cancer Research UK 16563Cancer Research UK C12292/A11174Cancer Research UK C1281/A12014Cancer Research UK C1287/A10710Cancer Research UK C1287/A12014Cancer Research UK C490/A10124Cancer Research UK C5047/A10692Cancer Research UK C5047/A15007Cancer Research UK C5047/A8384Cancer Research UK C8197/A16565Department of HealthMedical Research Council G0000934NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA128978NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA164920Wellcome Trust 068545/Z/02Wellcome Trust 076113Wellcome Trust 085475Wellcome Trust 090532/Z/09ZWellcome Trust WT084766/Z/08/Z
6 · The paper itself

Abstract

Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (r

Indexed as

AustraliaEndometrial NeoplasmsEndometriosisEndometriumFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideReceptor-Like Protein Tyrosine Phosphatases, Class 2STAT3 Transcription FactorPTPRD protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 2STAT3 protein, humanSTAT3 Transcription FactorCross-disease analysisendometrial cancerendometriosisgenetic correlationgenome-wide association study

Identifiers

PMID29608257
PMCPMC5943470
OpenAlexW2796053515

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.