ArticleArtificial organs2018
Cell Damage Index as Computational Indicator for Blood Cell Activation and Damage.
Article in Artificial organs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The influence of different surface texture parameters on the cell proliferation and adhesion early behaviors on the surface of titanium alloy.Frontiers in bioengineering and biotechnology · 2026Article
- Multi-scale simulation of red blood cell trauma in large-scale high-shear flows after Norwood operation.Computer methods and programs in biomedicine · 2025Article
- Effect of intercellular collisions on red blood cell membrane damage.Scientific reports · 2025Article
- Challenge of material haemocompatibility for microfluidic blood-contacting applications.Frontiers in bioengineering and biotechnology · 2023Review
- Numerical simulation of intracellular drug delivery via rapid squeezing.Biomicrofluidics · 2021Article
- PyOIF: Computational tool for modelling of multi-cell flows in complex geometries.PLoS computational biology · 2020Article
- Article
- Prediction of mechanical hemolysis in medical devices via a Lagrangian strain-based multiscale model.Artificial organs · 2020Article
- Applications of machine learning for simulations of red blood cells in microfluidic devices.BMC bioinformatics · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shear-induced hemolysis is a major concern in the design and optimization of blood-contacting devices. Even with a small amount of mechanical stress, inflammatory reactions can be triggered in the cells. Blood damage is typically estimated using continuum fluid dynamics simulations. In this study, we report a novel cell damage index (CDI) obtained by simulations on the single-cell level in a lattice Boltzmann fluid flow. The change of the cell surface area gives important information on mechanical stress of individual cells as well as for whole blood. We are using predefined basic channel designs to analyze and compare the newly developed CDI to the conventional blood damage calculations in very weak shear stress scenarios. The CDI can incorporate both volume fraction and channel geometry information into a single quantitative value for the characterization of flow in artificial chambers.
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Registered trials
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