ArticleInternal medicine (Tokyo, Japan)2018
Perforation and Postoperative Bleeding Associated with Endoscopic Submucosal Dissection in Colorectal Tumors: An Analysis of 398 Lesions Treated in Saga, Japan.
Article in Internal medicine (Tokyo, Japan), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Endoscopic submucosal dissection versus endoscopic mucosal resection for colorectal laterally spreading tumors (> 20 mm): a systematic review and meta-analysis.Techniques in coloproctology · 2026Pooled it
- Pooled it
- Review on colorectal endoscopic submucosal dissection focusing on the technical aspect.Surgical endoscopy · 2020Pooled it
- Clinical Outcomes of Rubber-clip-assisted Versus Conventional Colorectal Endoscopic Submucosal Dissection: A Retrospective Study.DEN open · 2027Article
- Endoscopic Closure After Colorectal ESD: A Literature Review and Meta-Analysis on Its Efficacy in Preventing Adverse Events.Diagnostics (Basel, Switzerland) · 2026Review
- Operative, safety and economic outcomes of endoscopic submucosal dissection in older adults: a retrospective real-world analysis.BMC gastroenterology · 2026Article
- Prophylactic Rectal ESD (Endoscopic Submucosal Dissection) Defect Closure and Post-ESD Clinical Outcomes: An International Multi-Center Study (with Video).Digestive diseases and sciences · 2025Article
- Advancements in endoscopic closure: Embracing a new era of managing complications and postprocedural defects after endoscopic submucosal dissection.World journal of gastrointestinal endoscopy · 2025Review
- Establishing a nomogram for predicting the risk factors for delayed bleeding after endoscopic submucosal dissection for colorectal tumors.International journal of colorectal disease · 2024Article
- Prophylactic clipping using the over-the-scope clip (OTSC) system after complex ESD and EMR of large colon polyps.Surgical endoscopy · 2023Article
- Complications after endoscopic submucosal dissection for early colorectal cancer (Review).Oncology letters · 2023Review
- Long-term clinical outcomes of endoscopic submucosal dissection in rectal neuroendocrine tumors based on resection margin status: a real-world study.Surgical endoscopy · 2023Article
- Short-term outcomes of patients undergoing endoscopic submucosal dissection for colorectal lesions.DEN open · 2023Article
- [Research Progress in Delayed Bleeding after Endoscopic Submucosal Dissection of Early-Stage Gastrointestinal Cancer].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Risk Stratification of Endoscopic Submucosal Dissection in Colon Tumors.Journal of clinical medicine · 2022Article
- Risk factors for delayed bleeding after endoscopic submucosal dissection of colorectal tumors.Surgical endoscopy · 2021Article
- Indications and outcomes of endoscopic resection for non-pedunculated colorectal lesions: A narrative review.World journal of gastrointestinal endoscopy · 2021Review
- Impact of obesity in colorectal endoscopic submucosal dissection: single-center retrospective cohort study.BMC gastroenterology · 2021Article
- Colorectal endoscopic mucosal resection with submucosal injection of epinephrine versus hypertonic saline in patients taking antithrombotic agents: propensity-score-matching analysis.BMC gastroenterology · 2019Article
- Delayed Bleeding After Colorectal Endoscopic Submucosal Dissection: When Is Emergency Colonoscopy Needed?Digestive diseases and sciences · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective The aim of this study was to clarify the safety of colorectal endoscopic submucosal dissection (ESD) during the era of health insurance coverage starting from April 2012 in Japan. Methods Between April 2012 and May 2016, ESD was applied to 398 lesions in 373 patients. Risk factors for serious complications of colorectal ESD, perforation and post-ESD bleeding, were evaluated focusing on the resected specimen size, location, growth pattern, invasion depth, histopathology, postoperative clipping, and procedure time. In addition, the relationship between serious complications and patients' background characteristics was analyzed. Results Among 373 patients, perforation occurred in 12 patients and post-ESD bleeding in 19 patients. A univariate analysis showed that the risk factors for perforation were the lesion size, the resected specimen size, and a long operation time. A multivariate analysis showed that a long operation time was a risk factor for perforation during colorectal ESD. A univariate analysis indicated that significant risk factors for postoperative bleeding were a long operation time, rectal lesion, and cancer. All patients with serious complications were treated by an endoscopic procedure without blood transfusion or the need to convert to open surgery. Conclusion The present study suggests that colorectal ESD may be accepted with relative safety in Japan as a common therapeutic approach for early colorectal cancer.
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