Evidence map›Paper›PMID 29607803›Full record

ReviewDeutsches Arzteblatt international2018

Molecular Imaging in Oncology Using Positron Emission Tomography.

Thorsten Derlin, Viktor Grünwald, Jörg Steinbach, Hans-Jürgen Wester, Tobias L Ross

Abstract readReview
In one paragraph

Review in Deutsches Arzteblatt international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
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  5. Review
  6. Article
  7. Review
  8. Current Status ofDiagnostics (Basel, Switzerland) · 2022
    Review
  9. Article
  10. Review
  11. Radiolabeling of functional oligonucleotides for molecular imaging.Frontiers in bioengineering and biotechnology · 2022
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. In Reply.Deutsches Arzteblatt international · 2018
    Article
  20. Some Necessary Additional Points.Deutsches Arzteblatt international · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Thorsten DerlinDepartment of Nuclear Medicine, Hannover Medical School; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden; Department of Pharmaceutical Radiochemistry, Technical University of Munich, Garching.
Viktor Grünwald
Jörg Steinbach
Hans-Jürgen Wester
Tobias L Ross

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnatomical and molecular data can be acquired simultaneously through the use of positron emission tomography (PET) in combination with computed tomography (CT) or magnetic resonance imaging (MRI) as a hybrid technique. A variety of radiopharmaceuticals can be used to characterize various metabolic processes or to visualize the expression of receptors, enzymes, and other molecular target structures.

methodsThis review is based on pertinent publications retrieved by a selective search in PubMed, as well as on guidelines from Germany and abroad and on systematic reviews and meta-analyses.

resultsEstablished radiopharmaceuticals for PET, such as 2-[18F]fluoro-2- deoxyglucose ([18F]FDG), enable the visualization of physiological processes on the molecular level and can provide vital information for clinical decision-making. For example, PET can be used to evaluate pulmonary nodules for malignancy with 95% sensitivity and 82% specificity. It can be used both for initial staging and for the guidance of further treatment. Alongside the PET radiopharmaceuticals that have already been well studied and evaluated, newer ones are increasingly becoming available for the noninvasive phenotyping of tumor diseases, e.g., for analyzing the expression of prostate-specific membrane antigen (PSMA), of somatostatin receptors, or of chemokine receptors on tumor cells.

conclusionPET is an important component of diagnostic algorithms in oncology. It can help make diagnosis more precise and treatment more individualized. An increasing number of PET radiopharmaceuticals are now expanding the available options for imaging. Many radiopharmaceuticals can be used not only for noninvasive analysis of the expression of therapeutically relevant target structures, but also for the ensuing, target-directed treatment with radionuclides.

Indexed as

GermanyHalf-LifeHumansMagnetic Resonance ImagingMolecular ImagingPositron-Emission TomographyRadiopharmaceuticalsTomography, X-Ray ComputedRadiopharmaceuticals

Identifiers

PMID29607803
PMCPMC5913576

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.