ArticleThe Angle orthodontist2018
Lithium chloride reduces orthodontically induced root resorption and affects tooth root movement in rats.
Article in The Angle orthodontist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Early apoptosis predicts orthodontically induced root resorption: inhibitory effects of lithium in a rat model.The Angle orthodontist · 2026Article
- Importance of the early phase of orthodontic force application in the induction of root resorption.The Angle orthodontist · 2025Article
- Effect of Lithium on Orthodontic Tooth Movement: a Systematic Review of Animal Studies.Turkish journal of orthodontics · 2024Article
- Lithium chloride stimulates bone formation in extraction socket repair in rats.Oral and maxillofacial surgery · 2024Article
- Lithium reduces orthodontically induced root resorption by suppressing cell death, hyalinization, and odontoclast formation in rats.The Angle orthodontist · 2022Article
- Sinomenine Inhibits Orthodontic Tooth Movement and Root Resorption in Rats and Enhances Osteogenic Differentiation of PDLSCs.Drug design, development and therapy · 2022Article
- Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy.Bioactive materials · 2021Article
- Lithium chloride assuages bone loss in experimental periodontitis in estrogen-deficient rats.Clinical oral investigations · 2020Article
- Effect of the software binning and averaging data during microcomputed tomography image acquisition.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the influence of lithium chloride (LiCl) on orthodontic tooth movement (OTM), orthodontically induced root resorption (OIRR), and bone morphometry. MATERIALS AND
methodsTen-week-old female Sprague Dawley rats (n = 32) were divided into four groups based on the concentration of LiCl administered daily per kilogram body weight: 0 (control group), 0.32, 0.64, and 1.28 mM/kg body weight. The maxillary left first molars were moved mesially by a 10 cN coil spring for 14 days. Micro-computed tomography, scanning electron microscope, and scanning laser microscope images were taken to measure the amount of OTM, the volume of OIRR, and bone morphometry.
resultsOIRR clearly decreased depending on the amount of LiCl administered, although OTM moderately decreased. The tooth inclined mesially and the root apex moved distally in the control and 0.32 mM groups. On the other hand, the tooth inclination angle became smaller and the root apex moved mesially in the 0.64 and 1.28 mM groups. In bone morphometry, the cortical bone mineral content and bone volume increased because of LiCl administration, and the trabecular bone measurements decreased. OIRR negatively correlated to the cortical bone measurements, and the amount of OTM significantly correlated to the cortical bone morphometry.
conclusionsIn rats, LiCl reduced OIRR, which induced mesial movement of the tooth root apex. OIRR positively correlated to cortical bone morphometry.
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