Evidence map›Paper›PMID 29607651›Full record

Observational studyAIDS research and human retroviruses2018

Lower Concentrations of Circulating Medium and Long-Chain Acylcarnitines Characterize Insulin Resistance in Persons with HIV.

Samuel S Bailin, Cathy A Jenkins, Christopher Petucci, Jeffrey A Culver, Bryan E Shepherd, Joshua P Fessel, Todd Hulgan, John R Koethe

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in AIDS research and human retroviruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Fatty Liver Disease: Enter the Metabolic Era.Current HIV/AIDS reports · 2023
    Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Samuel S Bailin1 Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee.
Cathy A Jenkins2 Department of Biostatistics, Vanderbilt University Medical Center , Nashville, Tennessee.
Christopher Petucci3 Sanford Burnham Prebys Metabolomics Core at the Southeast Center for Integrated Metabolomics, University of Florida , Gainesville, Florida.
Jeffrey A Culver3 Sanford Burnham Prebys Metabolomics Core at the Southeast Center for Integrated Metabolomics, University of Florida , Gainesville, Florida.
Bryan E Shepherd2 Department of Biostatistics, Vanderbilt University Medical Center , Nashville, Tennessee.
Joshua P Fessel4 Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center , Nashville, Tennessee.
Todd Hulgan5 Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, Tennessee.
John R Koethe5 Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, Tennessee.
Vanderbilt University Medical Center · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Southeast Resource Center for Integrated Metabolomics (SECIM)U24DK097209 · NIDDK · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S, YOST, RICHARD A. · 2013 to 2017
$9.2M
The Role of Adipose-Resident T Cells in HIV-Associated Glucose IntoleranceR01DK112262 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KOETHE, JOHN · 2017 to 2021
$3.8M
Metabolic Reprogramming in Pulmonary Arterial HypertensionK08HL121174 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FESSEL, JOSHUA PATRICK · 2014 to 2018
$723k
NCATS NIH HHS UL1 TR000445NHLBI NIH HHS K08 HL121174NIDDK NIH HHS R01 DK112262NIDDK NIH HHS U24 DK097209
6 · The paper itself

Abstract

In human immunodeficiency virus (HIV)-negative individuals, a plasma metabolite profile, characterized by higher levels of branched-chain amino acids (BCAA), aromatic amino acids, and C3/C5 acylcarnitines, is associated with insulin resistance and increased risk of diabetes. We sought to characterize the metabolite profile accompanying insulin resistance in HIV-positive persons to assess whether the same or different bioenergetics pathways might be implicated. We performed an observational cohort study of 70 nondiabetic, HIV-positive individuals (50% with body mass index ≥30 kg/m

Indexed as

Insulin ResistanceAdultAnti-Retroviral AgentsBlood Chemical AnalysisCarnitineCD4 Lymphocyte CountChromatography, GasChromatography, LiquidFemaleHIV InfectionsHumansMaleMass SpectrometryMetabolomicsMiddle AgedViral LoadacylcarnitineAnti-Retroviral AgentsCarnitinediabetes mellitusHIVinsulin resistancelipid metabolismmetabolomics

Identifiers

PMID29607651
PMCPMC5994672
OpenAlexW2795458644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.