Evidence map›Paper›PMID 29607568›Full record

Trial reportBritish journal of clinical pharmacology2018

Reducing potentially inappropriate drug prescribing in nursing home residents: effectiveness of a geriatric intervention.

Charlène Cool, Philippe Cestac, Cécile McCambridge, Laure Rouch, Philipe de Souto Barreto, Yves Rolland, Maryse Lapeyre-Mestre

Open access · bronzeAbstract readPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of clinical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Risk Indicators Improve the Prescription Quality of Drugs with Anticholinergic Properties in Nursing Homes.International journal of environmental research and public health · 2021
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Charlène CoolUMR INSERM 1027, University of Toulouse III, Toulouse, France.ORCID 0000-0002-7436-1568
Philippe CestacUMR INSERM 1027, University of Toulouse III, Toulouse, France.
Cécile McCambridgePôle Pharmacie, Centre Hospitalo-Universitaire (CHU) de Toulouse, 1 avenue Jean Poulhès, F 31059, Toulouse, France.
Laure RouchUMR INSERM 1027, University of Toulouse III, Toulouse, France.
Philipe de Souto BarretoGérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France.ORCID 0000-0002-8860-425X
Yves RollandUMR INSERM 1027, University of Toulouse III, Toulouse, France.
Maryse Lapeyre-MestreUMR INSERM 1027, University of Toulouse III, Toulouse, France.ORCID 0000-0002-5494-5873
Université Toulouse III - Paul Sabatier · FRCentre Hospitalier Universitaire de Toulouse · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPotentially inappropriate drug prescribing (PIDP) is frequent in nursing home (NH) residents. We aimed to investigate whether a geriatric intervention on quality of care reduced PIDP.

methodsWe performed an ancillary study within a multicentric individually-tailored controlled trial (IQUARE trial). All NH received a baseline and 18-month audit regarding drug prescriptions and other quality of care indicators. After the initial audit, NHs of the intervention group benefited of an in-site intervention (geriatric education for NH staff) provided by a geriatrician from the closest hospital. The analysis included 629 residents of 159 NHs. The main outcome was PIDP, defined as the presence of at least one of the following criteria: (i) drug with an unfavourable benefit-to-risk ratio; (ii) with questionable efficacy; (iii) absolute contraindication; (iv) significant drug-drug interaction. Multivariable multilevel logistic regression models were performed including residents and NH factors as confounders.

resultsPIDP was 65.2% (-3.6% from baseline) in the intervention group (n = 339) and 69.9% (-2.3%) in the control group (n = 290). The intervention significantly decreased PIDP [odds ratio (OR) = 0.63; 95% confidence interval 0.40-0.99], as a special care unit in NH (OR = 0.60; (0.42 to 0.85)), and a fall in the last 12 months (OR = 0.63; 0.44-0.90). Charlson Comorbidity Index [OR

conclusionThis intervention based on a global geriatric education resulted in a significant reduction of PIDP at patient level.

Indexed as

Quality ImprovementAgedAged, 80 and overDrug PrescriptionsDrug Utilization ReviewFemaleHealth PersonnelHumansInappropriate PrescribingLogistic ModelsMaleNursing HomesProgram EvaluationQuality of Health CareRisk Assessmentdrug utilizationelderlygeriatric medicinemedical educationprescribing

Identifiers

PMID29607568
PMCPMC6005629
OpenAlexW2795420742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.