ArticleThe Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians2017
In-Hospital Mortality Following Traumatic Brain Injury Among Older Medicare Beneficiaries, Comparing Statin Users With Nonusers.
Article in The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Pre-morbid statin use and mortality in trauma: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2026Pooled it
- Statins could improve short-term prognosis in patients with traumatic brain injury: a propensity-matched cohort study.Inflammopharmacology · 2025Article
- The protective effects of statins in traumatic brain injury.Pharmacological reports : PR · 2024Review
- The neuroprotective effect of statin in traumatic brain injury: A systematic review.World neurosurgery: X · 2023Review
- Prognosis prediction in traumatic brain injury patients using machine learning algorithms.Scientific reports · 2023Article
- Pitavastatin Ameliorates Lipopolysaccharide-Induced Blood-Brain Barrier Dysfunction.Biomedicines · 2021Article
- Inflammation in Traumatic Brain Injury.Journal of Alzheimer's disease : JAD · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundTraumatic brain injury (TBI) is a significant public health concern for older adults. Small-scale human studies have suggested pre-TBI statin use is associated with decreased in-hospital mortality following TBI, highlighting the need for large-scale translational research.
objectiveTo investigate the relationship between pre-TBI statin use and in-hospital mortality following TBI.
methodsA retrospective study of Medicare beneficiaries 65 and older hospitalized with a TBI during 2006 to 2010 was conducted to assess the impact of pre-TBI statin use on in-hospital mortality following TBI. Exposure of interest included atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, and simvastatin. Beneficiaries were classified as current, recent, past, and nonusers of statins prior to TBI. The outcome of interest was in-hospital mortality. Logistic regression was used to obtain odds ratios (ORs) and 95% confidence intervals (CIs) comparing current, recent, and prior statin use to nonuse.
resultsMost statin users were classified as current users (90%). Current atorvastatin (OR = 0.88; 95% = CI 0.82, 0.96), simvastatin (OR = 0.84; 95% CI = 0.79, 0.91), and rosuvastatin (OR = 0.79; 95% CI = 0.67, 0.94) use were associated with a significant decrease in the risk of in-hospital mortality following TBI.
conclusionsIn addition to being the most used statins, current use of atorvastatin, rosuvastatin, and simvastatin was associated with a significant decrease in in-hospital mortality following TBI among older adults. Future research must include clinical trials to help exclude the possibility of a healthy user effect in order to better understand the impact of statin use on in-hospital mortality following TBI.
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Registered trials
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