ArticleEndoscopy international open2018
Accuracy of probe-based confocal laser endomicroscopy (pCLE) compared to random biopsies during endoscopic surveillance of Barrett's esophagus.
Article in Endoscopy international open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advanced imaging (narrow band and acetic acid chromoendoscopy) and guided biopsies in surveillance of Barrett's oesophagus: a systematic review.BMJ open gastroenterology · 2026Pooled it
- Confocal laser endomicroscopy for upper gastrointestinal neoplasia: Systematic review and meta-analysis.Endoscopy international open · 2026Article
- Probe-based confocal laser endomicroscopy: progress, challenges, and emerging applications.Surgical endoscopy · 2025Review
- Review
- Progress in Probe-Based Sensing Techniques for In Vivo Diagnosis.Biosensors · 2022Review
- [Confocal probe localization algorithm based on region growing and endoscope size prior].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- Article
- The Use of Confocal Laser Endomicroscopy in Diagnosing Barrett's Esophagus and Esophageal Adenocarcinoma.Diagnostics (Basel, Switzerland) · 2022Review
- Today's Mistakes and Tomorrow's Wisdom in Endoscopic Imaging of Barrett's Esophagus.Visceral medicine · 2022Review
- SAGES TAVAC safety and efficacy analysis confocal laser endomicroscopy.Surgical endoscopy · 2021Review
- Reduced Intravenous Fluorescein Dose for Upper and Lower Gastrointestinal Tract Probe-Based Confocal Laser Endomicroscopy.Clinical endoscopy · 2021Article
- Deep learning systems detect dysplasia with human-like accuracy using histopathology and probe-based confocal laser endomicroscopy.Scientific reports · 2021Article
- Artificial Intelligence and Its Role in Identifying Esophageal Neoplasia.Digestive diseases and sciences · 2020Review
- Deep Learning for Whole-Slide Tissue Histopathology Classification: A Comparative Study in the Identification of Dysplastic and Non-Dysplastic Barrett's Esophagus.Journal of personalized medicine · 2020Article
- SCREENING FOR BARRETT'S ESOPHAGUS WITH PROBE-BASED CONFOCAL LASER ENDOMICROSCOPY VIDEOS.Proceedings. IEEE International Symposium on Biomedical Imaging · 2020Article
- Early Esophageal Cancer: A Gastroenterologist's Disease.Digestive diseases and sciences · 2019Review
- Barrett's esophagus: novel strategies for screening and surveillance.Therapeutic advances in chronic disease · 2019Review
- Near-infrared probe-based confocal microendoscope for deep-tissue imaging.Biomedical optics express · 2018Article
- Advances in Optical Coherence Tomography and Confocal Laser Endomicroscopy in Pulmonary Diseases.Respiration; international review of thoracic diseasesReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor surveillance of Barrett's esophagus (BE), the current standard of random 4-quadrant biopsies misses 10 - 50 % of esophageal neoplasms, and does not permit real-time decision-making. Probe-based confocal laser endomicroscopy (pCLE) permits real-time in vivo histologic assessment of esophageal mucosa during upper endoscopy. Prospective studies comparing the accuracy of pCLE to 4-quadrant biopsies in routine clinical practice are lacking.
methodsConsecutive patients with BE underwent high definition white light and narrow-band imaging followed by pCLE and targeted biopsy or mucosal resection. Four-quadrant biopsies were obtained during the same session. Baseline variables, real-time pCLE interpretation, and histology results were prospectively recorded. Blinded expert review of pCLE sequences and histology specimens was performed. A sample size of 64 patients was calculated a priori based on 3 % estimated prevalence of high grade dysplasia (HGD) or cancer.
resultsIn total, 66 patients were included in the study. The prevalence of HGD or cancer was 4.55 %. Both real-time and blinded pCLE correctly identified all cases of cancer. For the primary outcome, real-time pCLE was 98 % specific but only 67 % sensitive for HGD/cancer compared to non-blinded pathologist interpretation. For HGD and cancer, inter-observer agreement was substantial between real-time and blinded endomicroscopists (kappa = 0.6). pCLE identified dysplasia in 75 % of cases where both blinded and unblinded pathology interpretation was low grade dysplasia.
conclusionspCLE demonstrates high specificity for detecting dysplasia and cancer, but lower sensitivity may limit its utility in routine BE surveillance. pCLE may have a role in confirming LGD in real-time before eradication therapy.
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Registered trials
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