Evidence map›Paper›PMID 29607328›Full record

Trial reportBioMed research international2018

Maternal, Fetal, and Neonatal Outcomes in Pregnant Dengue Patients in Mexico.

Carlos Machain-Williams, Eric Raga, Carlos M Baak-Baak, Sungmin Kiem, Bradley J Blitvich, Celso Ramos

Open access · hybridAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Burden of Dengue in Pregnant Individuals: A Systematic Literature Review.The American journal of tropical medicine and hygiene · 2026
    Pooled it
  2. Pooled it
  3. Dengue and Zika Virus Diagnostic Testing for Patients with a Clinically Compatible Illness and Risk for Infection with Both Viruses.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2019
    Guideline
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Arboviruses and pregnancy: are the threats visible or hidden?Tropical diseases, travel medicine and vaccines · 2024
    Article
  11. Review
  12. Article
  13. Dengue in Pregnancy: A Southeast Asian Perspective.Tropical medicine and infectious disease · 2023
    Review
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Vector-borne diseases in pregnancy.Therapeutic advances in infectious disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Carlos Machain-WilliamsLaboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, YUC, Mexico.
Eric RagaDepartamento de Atención Médica, Servicios de Salud de Veracruz-Coordinación Clínica Médica, Instituto Mexicano del Seguro Social, Xalapa, VER, Mexico.
Carlos M Baak-BaakLaboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, YUC, Mexico.
Sungmin KiemDepartment of Infectious Diseases, Inje University, Haeundae Paik Hospital, Busan, Republic of Korea.
Bradley J BlitvichDepartment of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.ORCID 0000-0002-9857-5755
Celso RamosCentro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, MOR, Mexico.ORCID 0000-0002-4000-5848
Autonomous University of Yucatán · MXInje University Haeundae Paik Hospital · KRInstituto Nacional de Salud Pública · MXIowa State University · USMexican Social Security Institute · MX

Funding

Phenotypic characterization of T’Ho virus and the development of tools for its serologic diagnosisR03AI167042 · NIAID · IOWA STATE UNIVERSITY · PI BLITVICH, BRADLEY J · 2022 to 2023
$153k
NIAID NIH HHS R03 AI167042
6 · The paper itself

Abstract

To increase our understanding of the consequences of dengue virus infection during pregnancy, a retrospective analysis was performed on the medical records of all completed pregnancies (live births and pregnancy losses) at nine public hospitals in the Gulf of Mexico from January to October 2013. Eighty-two patients developed clinical, laboratory-confirmed dengue virus infections while pregnant. Of these, 54 (65.9%) patients were diagnosed with dengue without warning signs, 15 (18.3%) patients were diagnosed with dengue with warning signs, and 13 (15.9%) patients had severe dengue. Five (38.5%) patients with severe dengue experienced fetal distress and underwent emergency cesarean sections. Four patients delivered apparently healthy infants of normal birthweight while the remaining patient delivered a premature infant of low birthweight. Patients died of multiple organ failure during or within 10 days of the procedure. Severe dengue was also associated with obstetric hemorrhage (30.8%, four cases), preeclampsia (15.4%, two cases), and eclampsia (7.7%, one case). These complications were less common or absent in patients in the other two disease categories. Additionally, nonsevere dengue was not associated with maternal mortality, fetal distress, or adverse neonatal outcomes. In summary, the study provides evidence that severe dengue during pregnancy is associated with a high rate of fetal distress, cesarean delivery, and maternal mortality.

Indexed as

DengueInfant MortalityPregnancy Complications, InfectiousAbortion, SpontaneousAdultFemaleHumansInfantInfant, Low Birth WeightInfant, NewbornInfant, PrematureLive BirthMaternal MortalityMexicoPregnancy

Identifiers

PMID29607328
PMCPMC5828467
OpenAlexW2786728112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.