ArticleTranslational neuroscience2018
Further Evidence of Accelerated Aging in Bipolar Disorder: Focus on GDF-15.
Article in Translational neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Psychoeducational Program Increases Telomerase Activity in Bipolar Disorder: A Gender-Based Randomized Controlled Trial.CNS neuroscience & therapeutics · 2025Trial
- Biopsychosocial correlates of resting and stress-reactive salivary GDF15: preliminary findings.Brain, behavior, and immunity · 2025Article
- Pathophysiologic Mechanisms of Cardiovascular Disease in Patients With Bipolar Disorder.Cureus · 2025Review
- The conundrum of the connection between severe psychiatric disorders and dementia.Dementia & neuropsychologia · 2025Review
- Increased GDF-15 in chronic male patients with schizophrenia: correlation with body mass index and cognitive impairment.Schizophrenia (Heidelberg, Germany) · 2024Article
- Higher T central and lower effector memory cells in bipolar disorder: A differentiation abnormality?Brain, behavior, & immunity - health · 2024Article
- Bipolar disorder and the risk of cardiometabolic diseases, heart failure, and all-cause mortality: a population-based matched cohort study in South Korea.Scientific reports · 2024Article
- Linking hearts and minds: understanding the cardiovascular impact of bipolar disorder.Future cardiology · 2024Review
- The Italian Framework of Bipolar Disorders in the Elderly: Old and Current Issues and New Suggestions for the Geriatric Psycho-Oncology Research.Biomedicines · 2023Article
- Late-Life Depression is Associated With Increased Levels of GDF-15, a Pro-Aging Mitokine.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Article
- Deciphering the Causal Relationships Between Low Back Pain Complications, Metabolic Factors, and Comorbidities.Journal of pain research · 2022Article
- Mini-review: The anti-aging effects of lithium in bipolar disorder.Neuroscience letters · 2021Review
- Cardiovascular disease in patients with severe mental illness.Nature reviews. Cardiology · 2021Review
- Links between objective sleep and sleep variability measures and inflammatory markers in adults with bipolar disorder.Journal of psychiatric research · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters.
methodsForty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay.
resultsThe levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001).
conclusionOur findings corroborate the view that BD is an illness associated with accelerated aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.