Evidence map›Paper›PMID 29607179›Full record

ArticleJournal of thoracic disease2018

Modeling the relationship between baseline lactate dehydrogenase and prognosis in patients with extensive-disease small cell lung cancer: a retrospective cohort study.

Liang Zhou, Zhihui Xie, Zhenyi Shao, Wen Chen, Hua Xie, Xin Cui, Guoyou Qin, Naiqing Zhao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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  4. Central regulation of breast cancer growth and metastasis.Journal of cancer metastasis and treatment · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Liang ZhouDepartment of Biostatistics, School of Public Health, Fudan University and Key Lab of Health Technology Assessment, Ministry of Health (Fudan University), Shanghai 200032, China.
Zhihui XieInformation Center, Shanghai Municipal Commission of Health and Family Planning, Shanghai 200125, China.
Zhenyi ShaoInformation Center, Shanghai Municipal Commission of Health and Family Planning, Shanghai 200125, China.
Wen ChenInformation Center, Shanghai Municipal Commission of Health and Family Planning, Shanghai 200125, China.
Hua XieInformation Center, Shanghai Municipal Commission of Health and Family Planning, Shanghai 200125, China.
Xin CuiInformation Center, Shanghai Municipal Commission of Health and Family Planning, Shanghai 200125, China.
Guoyou QinDepartment of Biostatistics, School of Public Health, Fudan University and Key Lab of Health Technology Assessment, Ministry of Health (Fudan University), Shanghai 200032, China.
Naiqing ZhaoDepartment of Biostatistics, School of Public Health, Fudan University and Key Lab of Health Technology Assessment, Ministry of Health (Fudan University), Shanghai 200032, China.
Shanghai Municipal Commission of Health and Family Planning · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElevated pretreatment lactate dehydrogenase (LDH) has been reported to be associated with poor survival in small cell lung cancer (SCLC). The present study aimed to investigate the continuous relationship between baseline LDH level and survival in patients with extensive-disease SCLC (ED-SCLC).

methodsData were retrospectively collected from Shanghai Health Information Network. Patients primarily diagnosed as ED-SCLC from April 2011 to August 2014 were eligible for our study. Patients' survival status was checked in March 2016. A multivariate Cox proportional hazard model was used to detect the association between baseline serum LDH and overall survival. The corresponding continuous relationship was analyzed by using natural spline functions in the Cox model.

resultsA total of 132 eligible ED-SCLC patients were analyzed. Elevated LDH at baseline was associated with poor survival (HR =1.92; 95% CI, 1.29-2.86). An increment of LDH would still raise the risk of death even in abnormal range. Among patients with elevated LDH, those who had relatively higher LDH levels (>370 U/L) would have a poorer prognosis than those with moderately elevated LDH levels (245-370 U/L; median survival time, 114

conclusionsLDH is a significant prognostic biomarker for ED-SCLC patients. The interpretation of continuous relationship between LDH and patients' survival can provide more accurate information for clinical practice.

Indexed as

L-lactate dehydrogenase (LDH)prognosisretrospective studiesSmall cell lung cancer (SCLC)

Identifiers

PMID29607179
PMCPMC5864672
OpenAlexW2787733071

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.