ArticleJournal of thoracic disease2018
Effectiveness of high-flow nasal cannula oxygen therapy for acute respiratory failure with hypercapnia.
Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06257667 (Randomized Controlled Trial to Investigate the Effect of High Flow Nasal Cannula Treatment on Carbon Dioxide-levels in COPD- Patients With Acute Hypercapnic Respiratory Failure, Using Either OptiflowTM or Optiflow+DuetTM Nasal Cannula), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial to Investigate the Effect of High Flow Nasal Cannula Treatment on Carbon Dioxide-levels in COPD- Patients With Acute Hypercapnic Respiratory Failure, Using Either OptiflowTM or Optiflow+DuetTM Nasal Cannula
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- High-Flow Nasal Cannula in Hypercapnic Respiratory Failure: An Updated Systematic Review and Meta-Analysis.The clinical respiratory journal · 2026Pooled it
- High-flow nasal cannula versus non-invasive ventilation for acute hypercapnic respiratory failure in adults: a systematic review and meta-analysis of randomized trials.Critical care (London, England) · 2022Pooled it
- High flow nasal oxygen for acute type two respiratory failure: a systematic review.F1000Research · 2021Pooled it
- High-Flow Oxygen through Nasal Cannula vs. Non-Invasive Ventilation in Hypercapnic Respiratory Failure: A Randomized Clinical Trial.International journal of environmental research and public health · 2020Trial
- Clinical efficacy of high-flow nasal humidified oxygen therapy in patients with hypoxemia.PloS one · 2019Trial
- Management of hypercapnic acute respiratory failure with high-flow nasal cannula therapy: A narrative review.Annals of intensive care · 2026Review
- Gas composition and pressure in the hypopharynx during high-flow oxygen therapy through a nasal cannula in healthy volunteers with different breathing patterns.BMC anesthesiology · 2025Article
- High-flow oxygenation therapy for a sedated elderly frail patient with hiccups undergoing transcatheter aortic valve implantation.JA clinical reports · 2025Article
- Noninvasive respiratory support in the emergency department: Controversies and state-of-the-art recommendations.Journal of the American College of Emergency Physicians open · 2024Review
- Article
- Comparison of preoxygenation with a high-flow nasal cannula and a simple face mask before intubation in Korean patients with head and neck cancer.Acute and critical care · 2024Article
- Nebulization With Vibrating Mesh Through High-Flow Nasal Cannula: Why Is It Better?Respiratory care · 2024Article
- ERS International Congress 2022: highlights from the Respiratory Intensive Care Assembly.ERJ open research · 2023Review
- Article
- Current Practice of High Flow through Nasal Cannula in Exacerbated COPD Patients.Healthcare (Basel, Switzerland) · 2022Review
- High-flow nasal cannula oxygen therapy for admitted COPD-patients. A retrospective cohort study.PloS one · 2022Article
- Effects of high-flow nasal cannula in patients with mild to moderate hypercapnia: a prospective observational study.Acute and critical care · 2021Article
- Acute Responses to Oxygen Delivery via High Flow Nasal Cannula in Patients with Severe Chronic Obstructive Pulmonary Disease-HFNC and Severe COPD.Journal of clinical medicine · 2021Article
- High Flow Nasal Cannula Decreased Pulmonary Complications in Neurologically Critically Ill Patients.Frontiers in human neuroscience · 2021Article
- Sequential treatment of chronic obstructive pulmonary disease concurrent with respiratory failure by high-flow nasal cannula therapy.American journal of translational research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeated and humidified high-flow nasal cannula (HFNC) oxygen therapy has recently been introduced for hypoxic respiratory failure. However, it has not been well-evaluated for acute respiratory failure with hypercapnia.
methodsThis retrospective study included acute respiratory failure patients with hypercapnia in the medical intensive care unit (MICU) from April 2011 to February 2013, who required HFNC oxygen therapy for hypoxemia. Respiratory parameters were recorded and arterial blood gas analyses conducted before, and at 1 and 24 h after initiation of HFNC oxygen therapy.
resultsThirty-three patients were studied [median age, 72 years; range, 17-85 years; men, 24 (72.7%)]. Pneumonia (36.4%) and acute exacerbation of chronic obstructive pulmonary disease (33.4%) were the most common reasons for oxygen therapy. Most patients (60.6%) received oxygen therapy via nasal prong before HFNC application. The mean fraction of inspired oxygen (FiO
conclusionsHFNC oxygen therapy with sufficient FiO
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.