ReviewMemo2018
Anti-angiogenic therapies in brain metastases.
Review in Memo, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07383649 (Initial Safety Lead-in Followed by a Phase II Trial to Study Anti- HCMV Therapy in Breast Cancer Patients With Progressive Intracranial Metastases and CMV Infection), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Initial Safety Lead-in Followed by a Phase II Trial to Study Anti- HCMV Therapy in Breast Cancer Patients With Progressive Intracranial Metastases and CMV Infection (The Breast CMV Study)
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between graded prognostic assessment and the prognosis of brain metastases after whole brain radiotherapy: a meta-analysis.Frontiers in oncology · 2023Pooled it
- Multisite Benchmark Study for Standardized Relative CBV in Untreated Brain Metastases Using the DSC-MRI Consensus Acquisition Protocol.AJNR. American journal of neuroradiology · 2025Article
- Research progress on the role of Claudin family proteins in mediating blood-brain barrier selective permeability in tumor metastasis.American journal of translational research · 2025Review
- Developing a predictive model and uncovering immune influences on prognosis for brain metastasis from lung carcinomas.Frontiers in oncology · 2025Article
- Article
- The origin of brain malignancies at the blood-brain barrier.Cellular and molecular life sciences : CMLS · 2023Review
- Imaging angiogenesis in an intracerebrally induced model of brain macrometastasis using αNMR in biomedicine · 2023Article
- Article
- Associated Factors of Spontaneous Hemorrhage in Brain Metastases in Patients with Lung Adenocarcinoma.Cancers · 2023Article
- Brain Vascular Microenvironments in Cancer Metastasis.Biomolecules · 2022Review
- Article
- The Role of the Immune Response in Brain Metastases: Novel Imaging Biomarkers for Immunotherapy.Frontiers in oncology · 2021Review
- Combination of Immune Checkpoint Inhibitors and Anti-Angiogenic Agents in Brain Metastases From Non-Small Cell Lung Cancer.Frontiers in oncology · 2021Review
- Concurrent hepatocellular carcinoma metastasis to stomach, colon, and brain: A case report.World journal of clinical cases · 2020Article
- RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signaling.Oncology letters · 2020Article
- Clinical Response to Apatinib Combined With Brain Radiotherapy in EGFR Wild-Type and ALK-Negative Lung Adenocarcinoma With Multiple Brain Metastases.Frontiers in oncology · 2020Article
- N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1.Molecular cancer · 2019Article
- The Evolving Modern Management of Brain Metastasis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Review
- Bevacizumab-based treatment as salvage therapy in patients with recurrent symptomatic brain metastases.Neuro-oncology advancesArticle
- Continuous Low-Dose Apatinib Combined With WBRT Significantly Reduces Peritumoral Edema and Enhances the Efficacy of Symptomatic Multiple Brain Metastases in NSCLC.Technology in cancer research & treatmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain metastases are a major challenge in modern oncology, as treatment options upon the diagnosis of symptomatic brain metastases are limited. Neo-angiogenesis was identified as a hallmark of brain metastasis development and inhibition using anti-angiogenic therapy might therefore be an experimental promising preventive as well as therapeutic approach. The current review will summarize the current available data on the efficacy of neo-angiogenic therapies in patients with brain metastases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.