Evidence map›Paper›PMID 29606957›Full record

ArticleJournal of nanomaterials2015

Impact of Silver and Iron Nanoparticle Exposure on Cholesterol Uptake by Macrophages.

Jonathan H Shannahan, Hari Sowrirajan, Indushekhar Persaud, Ramakrishna Podila, Jared M Brown

Abstract read
In one paragraph

Article in Journal of nanomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Experimental challenges regarding the in vitro investigation of the nanoparticle-biocorona in disease states.Toxicology in vitro : an international journal published in association with BIBRA · 2018
    Article
  8. Review
  9. Article
  10. Article
  11. Pulmonary iron oxide (FeHuman & experimental toxicology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonathan H ShannahanDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Hari SowrirajanCherry Creek High School, Greenwood Village, CO 80111, USA.
Indushekhar PersaudDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Ramakrishna PodilaDepartment of Physics and Astronomy, Clemson University, Clemson, SC 29634, USA.
Jared M BrownDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Funding

Mechanisms of non-IgE Mast Cell Activation by Environmental ParticulatesR01ES019311 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI BROWN, JARED MICHAEL · 2010 to 2024
$7.0M
Disease-Induced Modification in Nanoparticle-Corona Identity and ToxicityR00ES024392 · NIEHS · PURDUE UNIVERSITY · PI SHANNAHAN, JONATHAN HENRY · 2017 to 2019
$747k
Disease-Induced Modification in Nanoparticle-Corona Identity and ToxicityK99ES024392 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI SHANNAHAN, JONATHAN HENRY · 2015 to 2016
$180k
NIEHS NIH HHS K99 ES024392NIEHS NIH HHS R00 ES024392NIEHS NIH HHS R01 ES019311
6 · The paper itself

Abstract

Macrophages are central to the development of atherosclerosis by absorbing lipids, promoting inflammation, and increasing plaque deposition. Nanoparticles (NPs) are becoming increasingly common in biomedical applications thereby increasing exposure to the immune and vascular systems. This project investigated the influence of NPs on macrophage function and specifically cholesterol uptake. Macrophages were exposed to 20 nm silver NPs (AgNPs), 110 nm AgNPs, or 20 nm Fe

Identifiers

PMID29606957
PMCPMC5875941

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.