Evidence map›Paper›PMID 29606955›Full record

ArticleDementia and geriatric cognitive disorders extra

An Estimate of Attributable Cases of Alzheimer Disease and Vascular Dementia due to Modifiable Risk Factors: The Impact of Primary Prevention in Europe and in Italy.

Flavia Mayer, Alessandra Di Pucchio, Eleonora Lacorte, Ilaria Bacigalupo, Fabrizio Marzolini, Gianluigi Ferrante, Valentina Minardi, Maria Masocco, Marco Canevelli, Teresa Di Fiandra and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  19. Attenuative Effects of Fluoxetine andMolecules (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Flavia MayerNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Alessandra Di PucchioNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Eleonora LacorteNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Ilaria BacigalupoNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Fabrizio MarzoliniNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Gianluigi FerranteNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Valentina MinardiNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Maria MasoccoNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Marco CanevelliDepartment of Human Neuroscience "Sapienza" University of Rome, Rome, Italy.
Teresa Di FiandraGeneral Direction of Prevention, Ministry of Health, Rome, Italy.
Nicola VanacoreNational Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
National Centre for Disease Prevention and Control · ITMinistero della Salute · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUp to 53.7% of all cases of dementia are assumed to be due to Alzheimer disease (AD), while 15.8% are considered to be due to vascular dementia (VaD). In Europe, about 3 million cases of AD could be due to 7 potentially modifiable risk factors: diabetes, midlife hypertension and/or obesity, physical inactivity, depression, smoking, and low educational level.

aimsTo estimate the number of VaD cases in Europe and the number of AD and VaD cases in Italy attributable to these 7 potentially modifiable risk factors.

methodsAssuming the nonindependence of the 7 risk factors, the adjusted combined population attributable risk (PAR) was estimated for AD and VaD.

resultsIn Europe, adjusted combined PAR was 31.4% for AD and 37.8% for VaD. The total number of attributable cases was 3,033,000 for AD and 873,000 for VaD. In Italy, assuming a 20% reduction of the prevalence of each risk factor, adjusted combined PAR decreased from 45.2 to 38.9% for AD and from 53.1 to 46.6% for VaD, implying a 6.4 and 6.5% reduction in the prevalence of AD and VaD, respectively.

conclusionA relevant reduction of AD and VaD cases in Europe and Italy could be obtained through primary prevention.

Indexed as

Alzheimer diseaseAttributable casesPreventionPublic healthVascular dementia

Identifiers

PMID29606955
PMCPMC5869579
OpenAlexW2792324842

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.