Evidence map›Paper›PMID 29606954›Full record

ArticleDementia and geriatric cognitive disorders extra

Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis.

Antti Cajanus, Anette Hall, Juha Koikkalainen, Eino Solje, Antti Tolonen, Timo Urhemaa, Yawu Liu, Ramona M Haanpää, Päivi Hartikainen, Seppo Helisalmi and 10 more

Abstract read
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. FTD spectrum: Neuroimaging across the FTD spectrum.Progress in molecular biology and translational science · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Antti CajanusInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Anette HallInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Juha KoikkalainenCombinostics Ltd., Tampere, Finland.
Eino SoljeInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Antti TolonenVTT Technical Research Centre of Finland Ltd., Tampere, Finland.
Timo UrhemaaVTT Technical Research Centre of Finland Ltd., Tampere, Finland.
Yawu LiuInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Ramona M HaanpääInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Päivi HartikainenInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Seppo HelisalmiInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Ville KorhonenInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Daniel RueckertDepartment of Computing, Imperial College London, London, United Kingdom.
Steen HasselbalchDanish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Gunhild WaldemarDanish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Patrizia MecocciSection of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
Ritva VanninenDepartment of Radiology, Kuopio University Hospital, Kuopio, Finland.
Mark van GilsVTT Technical Research Centre of Finland Ltd., Tampere, Finland.
Hilkka SoininenInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Jyrki LötjönenCombinostics Ltd., Tampere, Finland.
Anne M RemesInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWe assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD) from Alzheimer disease (AD), Lewy body dementia (LBD), and subjective memory complaints (SMC). We also examined the role of the

methodsThe MRI scans of 50 patients with bvFTD (17

resultsOnly VBM and VOL showed utility in correctly identifying bvFTD from our set of data. The overall classification sensitivity of bvFTD with VOL + VBM achieved a total sensitivity of 60%. Using VOL + VBM, 32% were misclassified as having LBD. There was a trend of higher values for classification sensitivity of the

conclusionVOL, VBM, and their combination are effective in differential diagnostics between bvFTD and AD or SMC. However, MRI atrophy profiles for bvFTD and LBD are too similar for a reliable differentiation with the quantification methods tested in this study.

Indexed as

DementiaFrontotemporal dementiaFrontotemporal lobar degenerationMachine learningMRINeuroimaging

Identifiers

PMID29606954
PMCPMC5869565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.