Evidence map›Paper›PMID 29606938›Full record

ArticleCase reports in gastroenterology

Spontaneous Hepatitis B Seroclearance upon Development of Hepatocellular Carcinoma.

Sara Naimimohasses, Omar El Sherif, Mohammad Ashfaq, Niamh Nolan, Masood Iqbal, Susan McKiernan, Suzanne Norris

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sara NaimimohassesDepartment of Hepatology, St. James' Hospital, Dublin, Ireland.
Omar El SherifDepartment of Hepatology, St. James' Hospital, Dublin, Ireland.
Mohammad AshfaqDepartment of Hepatology, St. James' Hospital, Dublin, Ireland.
Niamh NolanDepartment of Hepatology, St. James' Hospital, Dublin, Ireland.
Masood IqbalDepartment of Hepatology, St. James' Hospital, Dublin, Ireland.
Susan McKiernanDepartment of Hepatology, St. James' Hospital, Dublin, Ireland.
Suzanne NorrisDepartment of Hepatology, St. James' Hospital, Dublin, Ireland.
St. James's Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spontaneous seroclearance of hepatitis B upon development of a hepatocellular carcinoma (HCC) is extremely rare. To date, there has been one published case series reporting hepatitis B seroconversion following HCC resection. We describe two novel cases of spontaneous hepatitis B seroclearance following the development of HCC, prior to resection. Following resection, specimens were HBsAg- and HBcAg-negative in both tumor and peritumor tissues. Although the precise mechanism of this is poorly understood, nonuniform integration of hepatitis B virus DNA within the liver could lead to selective tumorigenesis of HBsAg-producing cells, explaining the observed clearance of serum HBsAg with the development of HCC.

Indexed as

CirrhosisHepatitis BHepatocellular carcinomaSeroclearanceSeroconversion

Identifiers

PMID29606938
PMCPMC5875296
OpenAlexW2777660853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.