Evidence map›Paper›PMID 29606908›Full record

ArticleCurrent genomics2018

Molecular Cytogenetic Analysis of One African and Five Asian Macaque Species Reveals Identical Karyotypes as in Mandrill.

Wiwat Sangpakdee, Alongkoad Tanomtong, Arunrat Chaveerach, Krit Pinthong, Vladimir Trifonov, Kristina Loth, Christiana Hensel, Thomas Liehr, Anja Weise, Xiaobo Fan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Wiwat SangpakdeeJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, D-07747Jena, Germany.
Alongkoad TanomtongDepartment of Biology, Faculty of Science, Khon Kaen University, 123 Moo 16 Mittapap Rd., Muang District, Khon Kaen40002, Thailand.
Arunrat ChaveerachDepartment of Biology, Faculty of Science, Khon Kaen University, 123 Moo 16 Mittapap Rd., Muang District, Khon Kaen40002, Thailand.
Krit PinthongJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, D-07747Jena, Germany.
Vladimir TrifonovJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, D-07747Jena, Germany.
Kristina LothSerengeti-Park Hodenhagen, Am Safaripark 1, D-29693 Hodenhagen, Germany.
Christiana HenselThüringer Zoopark Erfurt, Am Zoopark 1, D-99087Erfurt, Germany.
Thomas LiehrJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, D-07747Jena, Germany.
Anja WeiseJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, D-07747Jena, Germany.
Xiaobo FanJena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, D-07747Jena, Germany.
Jena University Hospital · DEKhon Kaen University · THFriedrich Schiller University Jena · DEThüringer Aufbaubank · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe question how evolution and speciation work is one of the major interests of biology. Especially, genetic including karyotypic evolution within primates is of special interest due to the close phylogenetic position of Macaca and Homo sapiens and the role as in vivo models in medical research, neuroscience, behavior, pharmacology, reproduction and Acquired Immune Deficiency Syndrome (AIDS). MATERIALS &

methodsKaryotypes of five macaque species from South East Asia and of one macaque species as well as mandrill from Africa were analyzed by high resolution molecular cytogenetics to obtain new insights into karyotypic evolution of old world monkeys. Molecular cytogenetics applying human probes and probe sets was applied in chromosomes of Macaca arctoides, M. fascicularis, M. nemestrina, M. assamensis, M. sylvanus, M. mulatta and Mandrillus sphinx. Established two- to multicolor-fluorescence in situ hybridization (FISH) approaches were applied. Locus-specific probes, whole and partial chromosome paint probes were hybridized. Especially the FISH-banding approach multicolor-banding (MCB) as well as probes oriented towards heterochromatin turned out to be highly efficient for interspecies comparison.

conclusionKaryotypes of all seven studied species could be characterized in detail. Surprisingly, no evolutionary conserved differences were found among macaques, including mandrill. Between the seven here studied and phenotypically so different species we expected several via FISH detectable karyoypic and submicroscopic changes and were surprised to find none of them on a molecular cytogenetic level. Spatial separation, may explain the speciation and different evolution for some of them, like African M. sylvanus, Mandrillus sphinx and the South Asian macaques. However, for the partially or completely overlapping habitats of the five studied South Asian macaques the species separation process can also not be deduced to karyotypic separation.

Indexed as

EvolutionMacaca arctoidesMacaca assamensisMacaca fascicularisMacaca mulattaMacaca nemestrinaMacaca sylvanusMandrillus sphinx

Identifiers

PMID29606908
PMCPMC5850509
OpenAlexW2736769223

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.