ArticleOncoTargets and therapy2018
Open adrenalectomy versus laparoscopic adrenalectomy for adrenocortical carcinoma: a retrospective comparative study on short-term oncologic prognosis.
Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Comparing the efficacy and safety of laparoscopic and robotic adrenalectomy: a meta-analysis and trial sequential analysis.Langenbeck's archives of surgery · 2020Pooled it
- Analysis of clinical and pathological characteristics of classic adrenocortical carcinoma.Scientific reports · 2026Article
- Laparoscopic or Open Adrenalectomy for Stage I-II Adrenocortical Carcinoma: A Retrospective Study.Journal of clinical medicine · 2023Article
- Pathological and clinical outcomes of adrenalectomy: A multi-center experience in Saudi Arabia.Saudi journal of biological sciences · 2023Article
- Surgical Management of Adrenocortical Carcinoma: A Literature Review.Journal of clinical medicine · 2022Review
- Postoperative outcomes of minimally invasive adrenalectomy: do body mass index and tumor size matter? A single-center experience.BMC surgery · 2022Review
- Adjuvant therapy in adrenocortical carcinoma: prognostic factors and treatment options.Endocrine oncology (Bristol, England) · 2022Review
- Surgical Management of Adrenocortical Carcinoma: Current Highlights.Biomedicines · 2021Review
- Open versus minimally invasive surgery for suspected adrenocortical carcinoma.Translational andrology and urology · 2021Review
- Preoperative Detection of Liver Involvement by Right-Sided Adrenocortical Carcinoma Using CT and MRI.Cancers · 2021Article
- Robotic renal and adrenal oncologic surgery: A contemporary review.Asian journal of urology · 2021Review
- Laparoscopic and robot-assisted transperitoneal lateral adrenalectomy: a large clinical series from a single center.Updates in surgery · 2020Article
- Comparative Performance of the 7th and 8th Editions of the American Joint Committee on Cancer Staging Manual for Adrenocortical Carcinoma.World journal of surgery · 2020Article
- Laparoscopic resection of giant adrenal malignant tumors, a case series and review of the literature.AME case reports · 2020Article
- Minimally invasive adrenalectomy for adrenocortical cancers: A systematic review.Indian journal of urology : IJU : journal of the Urological Society of IndiaReview
- Clinicopathological features and outcomes of adrenocortical carcinoma: A single institution experience.Indian journal of urology : IJU : journal of the Urological Society of IndiaArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOpen adrenalectomy (OA) remains the gold standard of surgical therapy for adrenocortical carcinoma, while the role of laparoscopic approach is controversial. We aim to explore the influence of surgical approaches on the oncologic prognosis of adrenocortical carcinoma by comparing the short-term outcomes of patients undergoing OA with those undergoing laparoscopic adrenalectomy (LA). PATIENTS AND
methodsWe retrospectively analyzed the baseline characteristics, perioperative data and short-term prognosis of 42 patients diagnosed with stage I-III adrenocortical carcinoma, receiving OA (n=22) and LA (n=20) as primary therapy. The primary end point was the first recurrence.
resultsOA group had larger mean maximum diameter of tumor (10.1±3.6 versus 6.3±2.2 cm) and lesser benefits in operative time, bleeding loss and postoperative hospital stay than laparoscopic group. Mean disease-free survival (DFS) of OA was 44.8±35.1 months, which was longer than 17.5±10.4 months of LA, and the rate of 2-year DFS after primary surgery in the open group was higher than in the laparoscopic group (61.1% versus 21.4%, respectively). Rates of 1- and 3-year DFS showed no significant difference. All patients undergoing LA (11/11) showed local recurrent lesions at the first time of recurrence, while 5 of 13 patients undergoing OA did not show local recurrence (
conclusionOA for adrenocortical carcinoma is superior to laparoscopic approach in terms of DFS and rate of 2-year DFS, in spite of the larger maximum diameter of tumors and lesser benefit during perioperation. After LA, patients are more likely to show local recurrent lesions at the first time of relapse.
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