Evidence map›Paper›PMID 29606867›Full record

ArticleInternational journal of nanomedicine2018

NaCl: for the safer in vivo use of antibacterial silver based nanoparticles.

Mingzhuo Liu, Huiqing Zhang, Xiangwei Song, Chaochao Wei, Zhenfang Xiong, Fen Yu, Chen Li, Fanrong Ai, Guanghua Guo, Xiaolei Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mingzhuo LiuDepartment of Burns, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Huiqing ZhangDepartment of Burns, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Xiangwei SongDepartment of Translational Medicine, Nanchang University, Nanchang, Jiangxi, China.
Chaochao WeiDepartment of Translational Medicine, Nanchang University, Nanchang, Jiangxi, China.
Zhenfang XiongDepartment of Pathology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Fen YuDepartment of Translational Medicine, Nanchang University, Nanchang, Jiangxi, China.
Chen LiDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Fanrong AiSchool of Mechanical & Electronic Engineering, Nanchang University, Nanchang, Jiangxi, China.
Guanghua Guo *Department of Burns, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
Xiaolei Wang *Department of Translational Medicine, Nanchang University, Nanchang, Jiangxi, China.
First Affiliated Hospital of Nanchang University · CNNanchang University · CNSecond Affiliated Hospital of Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs antibiotics progressively cease to be effective, silver based nanoparticles (SBNs), with broad antibacterial spectrum, might be the last line of defense against malicious bacteria. Unfortunately, there are still no proper SBNs-based strategies for in vivo antibacterial therapies. In this article, new carbon membrane packaged Ag nanoparticles (Ag-C) were synthesized. We assessed the effect of Ag-C with NaCl on size, cytotoxicity, antibacterial properties, metabolism and sepsis models.

methodsThe size of Ag-C with NaCl was accessed with UV-vis, TEM and SEM.

resultsNaCl could regulate the size of Ag-C. Ag-C exhibited superior antibacterial properties compared to similar sized pure Ag nanoparticles. Furthermore, the addition of NaCl could not only reduce the cytotoxicity of Ag-C, but could also continue to discharge Ag-C from major organs. Based on these factors, this method was used to treat a sepsis model (induced via cecal ligation and puncture), and it achieved satisfactory survival results.

conclusionThis discovery, though still in its infancy, could significantly improve the safety and feasibility of SBNs and could potentially play an important role in modern in vivo antibacterial applications. Thus, a new method to combating the growing threat from drug-resistant bacteria could be possible. NaCl is the key to excretion of SBNs after in vivo antibacterial use.

Indexed as

AnimalsAnti-Bacterial AgentsBacteremiaEscherichia coliMaleMetal NanoparticlesMiceMicrobial Sensitivity TestsMicroscopy, Electron, ScanningParticle SizePseudomonas aeruginosaSilverSodium ChlorideSpectrophotometry, UltravioletStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsSilverSodium ChlorideAg nanoparticlesantibacterialcytotoxicitymetabolismNaCl

Identifiers

PMID29606867
PMCPMC5868575
OpenAlexW2791549689

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.