ArticleThe journal of sexual medicine2018
S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism.
Article in The journal of sexual medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- S-nitrosylation of CSF1 receptor increases the efficacy of CSF1R blockage against prostate cancer.Cell death & disease · 2022Article
- Vascular dysfunction and increased cardiovascular risk in hypospadias.European heart journal · 2022Article
- Age Induced Nitroso-Redox Imbalance Leads to Subclinical Hypogonadism in Male Mice.Frontiers in endocrinology · 2019Article
- Effect of nitroso-redox imbalance on male reproduction.Translational andrology and urology · 2018Review
- Alterations of tumor microenvironment by nitric oxide impedes castration-resistant prostate cancer growth.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Yin Yang Role of Nitric Oxide in Prostate Cancer.American journal of men's healthReview
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundExcess reactive oxygen species and reactive nitrogen species are implicated in male infertility and impaired spermatogenesis.
aimTo investigate the effect of excess reactive nitrogen species and nitrosative stress on testicular function and the hypothalamic-pituitary-gonadal axis using the S-nitrosoglutathione reductase-null (Gsnor
methodsTestis size, pup number, and epididymal sperm concentration and motility of Gsnor OUTCOMES: Evaluation of fertility and reproductive hormones in Gsnor
resultsGsnor CLINICAL TRANSLATION: These findings provide novel insight to a possible mechanism of secondary hypogonadism from increased reactive nitrogen species and excess nitrosative stress. STRENGTHS AND LIMITATIONS: Limitations of this study are its small samples and variability in hormone levels.
conclusionDeficiency of S-nitrosoglutathione reductase results in secondary hypogonadism, suggesting that excess nitrosative stress can affect LH production from the pituitary gland. Masterson TA, Arora H, Kulandavelu S, et al. S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism. J Sex Med 2018;15:654-661.
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Registered trials
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