ArticleStructure (London, England : 1993)2018
A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.
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Article in Structure (London, England : 1993), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
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Who cites it
37 citing papers in PubMed, 48 citations in OpenAlex.
- Calmodulin enhancement of mitochondrial calcium uniporter function in isolated mitochondria.Cell calcium · 2025Article
- Oligomerization Function of the Native Exon 5 Sequence of Ameloblastin Fused with Calmodulin.ACS omega · 2025Article
- Laminin Alpha 2 Enhances the Protective Effect of Exosomes on Human iPSC-Derived Cardiomyocytes in an In Vitro Ischemia-Reoxygenation Model.International journal of molecular sciences · 2024Article
- Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation.International journal of molecular sciences · 2023Review
- Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms.Cell calcium · 2023Article
- Feedback contributions to excitation-contraction coupling in native functioning striated muscle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Binding by calmodulin is coupled to transient unfolding of the third FF domain of Prp40A.Protein science : a publication of the Protein Society · 2023Article
- Calmodulin mutations affecting Gly114 impair binding to the NaFrontiers in pharmacology · 2023Article
- Machine learning in computational modelling of membrane protein sequences and structures: From methodologies to applications.Computational and structural biotechnology journal · 2023Review
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- NaStructure (London, England : 1993) · 2021Article
- Ca2+-dependent modulation of voltage-gated myocyte sodium channels.Biochemical Society transactions · 2021Review
- A Review of Calcineurin Biophysics with Implications for Cardiac Physiology.International journal of molecular sciences · 2021Review
- Ventricular voltage-gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation.Clinical and translational medicine · 2021Review
- Calmodulin Interactions with Voltage-Gated Sodium Channels.International journal of molecular sciences · 2021Review
- Elementary mechanisms of calmodulin regulation of NaProceedings of the National Academy of Sciences of the United States of America · 2021Article
- A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Properties of Calmodulin Binding to NaNeurochemical research · 2021Article
- Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation.The Journal of general physiology · 2021Review
- Disrupting polycystin-2 EF hand CaJournal of cell science · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Christopher N JohnsonDivision of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37240, USA; Department of Biochemistry, Vanderbilt University, Nashville, TN 37205, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA; Center for Arrhythmia Research and Therapeutics, Vanderbilt University, Nashville, TN 37240, USA. Electronic address: cn.johnson@vanderbilt.edu.
Franck PotetDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago IL 60611, USA.
Matthew K ThompsonDepartment of Biochemistry, Vanderbilt University, Nashville, TN 37205, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.
Brett M KronckeDivision of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37240, USA; Center for Arrhythmia Research and Therapeutics, Vanderbilt University, Nashville, TN 37240, USA.
Andrew M GlazerDivision of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37240, USA; Center for Arrhythmia Research and Therapeutics, Vanderbilt University, Nashville, TN 37240, USA.
Markus W VoehlerDepartment of Chemistry, Vanderbilt University, Nashville, TN 37235, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.
Bjorn C KnollmannDivision of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37240, USA; Center for Arrhythmia Research and Therapeutics, Vanderbilt University, Nashville, TN 37240, USA.
Alfred L GeorgeDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago IL 60611, USA.
Walter J ChazinDepartment of Biochemistry, Vanderbilt University, Nashville, TN 37205, USA; Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: walter.chazin@vanderbilt.edu.
Vanderbilt University · USNorthwestern University · US
Funding
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI MARC ALLAIRE · 2017 to 2026
$28.6MMOLECULAR BIOPHYSICS TRAINING PROGRAM AT VANDERBILTT32GM008320 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J. · 1989 to 2023
$7.9MStructural Biology of Multi-Domain Proteins and Multi-Protein Machinery in DNA Replication and RepairR35GM118089 · NIGMS · VANDERBILT UNIVERSITY · PI WALTER J. CHAZIN · 2016 to 2026
$4.9MTroponin T mutations and Sudden Cardiac DeathR01HL071670 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2003 to 2017
$4.5MTRAINING PROGRAM IN ION CHANNEL AND TRANSPORTER BIOLOGYT32NS007491 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENTON, JEROD S. · 2001 to 2020
$4.1MNeonatal Long QT Syndrome and Sudden Infant DeathR01HL083374 · NHLBI · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L. · 2007 to 2015
$2.9MMINOS (Macromolecular Insights on Nucleic acids Optimized by Scattering)R01GM105404 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI TAINER, JOHN A. · 2012 to 2015
$2.1MA Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998kHigh-Performance Computer Cluster for Biomedical ResearchS10OD023680 · OD · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2017 to 2017
$587kConsole upgrades for biological NMR spectrometersS10RR025677 · NCRR · VANDERBILT UNIVERSITY · PI SANDERS, CHARLES R · 2009 to 2009
$460kHigh-throughput Discovery of Pathogenic Cardiac Sodium Channel VariantsF32HL137385 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, ANDREW M. · 2017 to 2019
$133kStructural / functional basis of CaM dependent modulation of NaV1.5 inactivationF32HL117612 · NHLBI · VANDERBILT UNIVERSITY · PI JOHNSON, CHRISTOPHER N. · 2013 to 2015
$88kNCRR NIH HHS S10 RR025677NHLBI NIH HHS F32 HL117612NHLBI NIH HHS F32 HL137385NHLBI NIH HHS R01 HL071670NHLBI NIH HHS R01 HL083374NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM105404NIGMS NIH HHS R35 GM118089NIGMS NIH HHS T32 GM008320NIH HHS S10 OD018483NIH HHS S10 OD023680NINDS NIH HHS T32 NS007491
Abstract
The function of the human cardiac sodium channel (Na
Indexed as
Binding SitesCalciumCalmodulinCrystallography, X-RayGene Expression RegulationHumansKineticsModels, MolecularMutationNAV1.5 Voltage-Gated Sodium ChannelProtein BindingCalciumCalmodulinNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humancalcium regulationcardiac sodium channel (NaV1.5)small angle X-ray scattering (SAXS)solution NMR spectroscopystructural biologywhole-cell patch-clamp electrophysiologyX-ray crystallography
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.