ArticleNeuron2018
Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength.
Open access · hybridAbstract read
In one paragraph
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
10.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.
- Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states.Genome research · 2022Pooled it
- Astrocytes in Neurodegeneration: Spatial States, Crosstalk, and Emerging Therapies.Molecular neurobiology · 2026Review
- Bridging the gap: neuroinflammation and the dawn of precision medicine in amyotrophic lateral sclerosis.Translational neurodegeneration · 2026Review
- Progressive gait and motor deficits in a rat model of Alexander disease.Behavioural brain research · 2026Article
- Astrocyte Regulation of Spinal Circuit Function.Journal of neurochemistry · 2026Review
- Astrocytic KFrontiers in aging neuroscience · 2026Review
- Defining spinal motor neuron subtypes across development: from embryonic specification to postnatal maturation.Frontiers in cellular neuroscience · 2026Review
- Intrinsically accelerated cellular degradation is amplified by TDP-43 loss in ALS-vulnerable motor neurons in a zebrafish model.Nature communications · 2025Article
- Mechanistic correlation of potassium channel sensing and nitric oxide activity in neuroinflammation.Molecular biology reports · 2025Review
- Nanoemulsions of Cannabidiol, Δ9-Tetrahydrocannabinol, and Their Combination Similarly Exerted Anticonvulsant and Antioxidant Effects in Mice Treated with Pentylenetetrazole.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Astrocyte Kir4.1 expression level territorially controls excitatory transmission in the brain.Cell reports · 2025Article
- Sex-specific astrocyte regulation of spinal motor circuits by Nkx6.1.Cell reports · 2025Article
- Preclinical Insights into the Role of Kir4.1 in Chronic Pain and Depression: Mechanisms and Therapeutic Potential.Biomolecules · 2025Review
- Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling.Neurochemical research · 2025Article
- Progress of Astrocyte-Neuron Crosstalk in Central Nervous System Diseases.Neurochemical research · 2024Review
- Astrocytic inhibition of lateral septal neurons promotes diverse stress responses.Nature communications · 2024Article
- Developmental origin of oligodendrocytes determines their function in the adult brain.Nature neuroscience · 2024Article
- Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses.Nature chemical biology · 2024Article
- Dam antidepressants.Nature chemical biology · 2024Article
- Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 2 countries.
Kevin W KelleyEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Departments of Pediatrics and Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Lucile Ben HaimEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Departments of Pediatrics and Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Lucas SchirmerEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Departments of Pediatrics and Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Giulia E TyzackDepartment of Molecular Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK; The Francis Crick Institute, London NW1 1AT, UK.
Michaela TolmanSackler School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
John G MillerDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA.
Hui-Hsin TsaiEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Departments of Pediatrics and Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Sandra M ChangEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Departments of Pediatrics and Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Anna V MolofskyDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA.
Yongjie YangSackler School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
Rickie PataniDepartment of Molecular Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK; The Francis Crick Institute, London NW1 1AT, UK.
Andras LakatosJohn van Geest Centre for Brain Repair and Department of Clinical Neurosciences, University of Cambridge, Cambridge CB20QQ, UK.
Erik M UllianDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143, USA.
David H RowitchEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Departments of Pediatrics and Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Paediatrics and Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20QQ, UK. Electronic address: dhr25@medschl.cam.ac.uk.
University of California, San Francisco · USBroad Center · USTufts University · USThe Francis Crick Institute · GBUniversity College London · GBUniversity of Cambridge · GBWellcome/MRC Cambridge Stem Cell Institute · GB
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MRapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAKKARAJU, APARNA · 1985 to 2024
$16.8MOLIGODENDROCYTE LINEAGE GENE FUNCTION IN THE CNSR01NS040511 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROWITCH, DAVID H · 2000 to 2014
$6.4MAstrolglia-Mediated Pathogenic Mechanisms in Fragile X Syndrome (FXS)R01MH106490 · NIMH · TUFTS UNIVERSITY BOSTON · PI YANG, YONGJIE · 2016 to 2025
$3.3MRegion-restricted astrocytes in neural circuit formation and functionK08MH104417 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ANNA V · 2014 to 2017
$705kMedical Research Council MC_PC_12009Medical Research Council MR/P008658/1Medical Research Council MR/S006591/1NEI NIH HHS P30 EY002162NIGMS NIH HHS T32 GM007618NIMH NIH HHS K08 MH104417NIMH NIH HHS R01 MH106490NINDS NIH HHS R01 NS040511Wellcome Trust
Abstract
Diversified neurons are essential for sensorimotor function, but whether astrocytes become specialized to optimize circuit performance remains unclear. Large fast α-motor neurons (FαMNs) of spinal cord innervate fast-twitch muscles that generate peak strength. We report that ventral horn astrocytes express the inward-rectifying K
Indexed as
Amyotrophic Lateral SclerosisAnimalsAnimals, NewbornAstrocytesCells, CulturedFemaleHumansInduced Pluripotent Stem CellsKcnj10 ChannelMaleMiceMice, TransgenicMotor NeuronsOrgan Culture TechniquesPotassium Channels, Inwardly RectifyingKcnj10 ChannelPotassium Channels, Inwardly Rectifyingamyotrophic lateral sclerosisastrocyte diversityfast-twitch muscleKir4.1motor neuronneurodegenerationpeak strengthspinal cord development
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.