Evidence map›Paper›PMID 29606560›Full record

ReviewDevelopmental cognitive neuroscience2018

Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data.

Kristina A Uban, Megan K Horton, Joanna Jacobus, Charles Heyser, Wesley K Thompson, Susan F Tapert, Pamela A F Madden, Elizabeth R Sowell, Adolescent Brain Cognitive Development Study

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Developmental cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 126 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 3 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 3 syntheses or guidelines pooled it, 185 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. From adolescence to Alzheimer's: a neurodevelopmental lifespan model of cognitive vulnerability.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  6. Article
  7. Longitudinal neurocognitive trajectories in a large cohort of youth who use cannabis: combining self-report and toxicology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Connecting the Dots: The Role of Pediatric Concussion on Pubertal Hormones and Psychological Health.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kristina A UbanDepartment of Pediatrics, Keck School of Medicine, University of Southern California, and Children's Hospital Los Angeles, Los Angeles, CA, USA.
Megan K HortonIcahn School of Medicine at Mount Sinai, Department of Environmental Medicine and Public Health, New York, NY, USA.
Joanna JacobusDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Charles HeyserSchool of Medicine, University of California San Diego, La Jolla, CA, USA.
Wesley K ThompsonDepartment of Family Medicine and Public Health, Division of Biostatistics, University of California San Diego, La Jolla, CA, USA.
Susan F TapertDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Pamela A F MaddenWashington University, School of Medicine, Department of Psychiatry, St. Louis, MO, USA. Electronic address: pmadden@wustl.edu.
Elizabeth R SowellDepartment of Pediatrics, Keck School of Medicine, University of Southern California, and Children's Hospital Los Angeles, Los Angeles, CA, USA. Electronic address: esowell@chla.usc.edu.
Adolescent Brain Cognitive Development Study
University of California San Diego · USUniversity of Southern California · USIcahn School of Medicine at Mount Sinai · USWashington University in St. Louis · US

Funding

ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
Assessing Stable Characteristics of Endocrine Function Among Boys and Girls with Prenatal Alcohol Exposure as a Novel Clinical ToolK01AA026889 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI UBAN, KRISTINA ANDREA · 2018 to 2022
$894k
NCATS NIH HHS KL2 TR001444NIAAA NIH HHS K01 AA026889NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041120NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147
6 · The paper itself

Abstract

Biospecimen collection in the Adolescent Brain Cognitive Development (ABCD) study - of hair samples, shed deciduous (baby) teeth, and body fluids - will serve dual functions of screening for study eligibility, and providing measures of biological processes thought to predict or correlate with key study outcomes on brain and cognitive development. Biosamples are being collected annually to screen for recency of drug use prior to the neuroimaging or cognitive testing visit, and to store for the following future studies: (1) on the effects of exposure to illicit and recreational drugs (including alcohol and nicotine); (2) of pubertal hormones on brain and cognitive developmental trajectories; (3) on the contribution of genomics and epigenomics to child and adolescent development and behavioral outcomes; and (4) with pre- and post-natal exposure to environmental neurotoxicants and drugs of abuse measured from novel tooth analyses. The present manuscript describes the rationales for inclusion and selection of the specific biospecimens, methodological considerations for each measure, future plans for assessment of biospecimens during follow-up visits, and preliminary ABCD data to illustrate methodological considerations.

Indexed as

AdolescentAdolescent DevelopmentBrainChildCognitionFemaleHumansNeuroimagingSpecimen HandlingABCD studyBiospecimensEnvironmental exposuresGeneticsGonadal hormonesSubstance use

Identifiers

PMID29606560
PMCPMC6487488
OpenAlexW2790273005

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.