Evidence map›Paper›PMID 29606496›Full record

ArticleCell host & microbe2018

Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus.

Jagadish Beloor, Nyree Maes, Irfan Ullah, Pradeep Uchil, Andrew Jackson, Erol Fikrig, Sang Kyung Lee, Priti Kumar

Abstract read
In one paragraph

Article in Cell host & microbe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Current trends in targeted therapy for drug-resistant infections.Applied microbiology and biotechnology · 2019
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jagadish BeloorDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.
Nyree MaesDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.
Irfan UllahDepartment of Bioengineering and Institute of Nanoscience and Technology, Hanyang University, Seoul 133-791, Korea.
Pradeep UchilDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Andrew JacksonDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.
Erol FikrigDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.
Sang Kyung LeeDepartment of Bioengineering and Institute of Nanoscience and Technology, Hanyang University, Seoul 133-791, Korea. Electronic address: sangkyunglee@hanyang.ac.kr.
Priti KumarDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: priti.kumar@yale.edu.

Funding

Predoctoral Training Program in VirologyT32AI055403 · NIAID · YALE UNIVERSITY · PI KUMAR, PRITI, MOTHES, WALTHER H · 2003 to 2024
$3.6M
In vivo genomic editing of hematopoietic cells for HIV resistanceR01AI112443 · NIAID · YALE UNIVERSITY · PI GLAZER, PETER M, KUMAR, PRITI · 2014 to 2017
$2.1M
Exploring antibody-Fc effector function in humanized mouse models of HIV latencyR33AI122384 · NIAID · YALE UNIVERSITY · PI KUMAR, PRITI, SUTTON, RICHARD · 2018 to 2020
$1.5M
Exploring antibody-Fc effector function in humanized mouse models of HIV latencyR21AI122384 · NIAID · YALE UNIVERSITY · PI KUMAR, PRITI, SUTTON, RICHARD · 2016 to 2017
$464k
NIAID NIH HHS R01 AI112443NIAID NIH HHS R21 AI122384NIAID NIH HHS R33 AI122384NIAID NIH HHS T32 AI055403
6 · The paper itself

Abstract

No vaccines or therapeutics are licensed for West Nile virus (WNV), a mosquito-transmitted neuroencephalitic flavivirus. The small interfering RNA siFvE

Indexed as

Drug CarriersAnimalsBrainDisease Models, AnimalMicePlacebosRabies virusRNA, Small InterferingSurvival AnalysisVirus ReplicationWest Nile FeverWest Nile virusDrug CarriersPlacebosRNA, Small InterferingCNS deliveryflavivirusintranasal treatmentnatural immunityrabies virus glycoproteinsiRNAtherapeuticsWest Nile virus

Identifiers

PMID29606496
PMCPMC6074029

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.