Evidence map›Paper›PMID 29606372›Full record

ArticleBiological psychiatry2018

Meeting Report: Can We Make Animal Models of Human Mental Illness?

Lisa M Monteggia, Hakon Heimer, Eric J Nestler

Open access · greenAbstract read
In one paragraph

Article in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Quo Vadis translational neuroscience?Translational neuroscience · 2026
    Review
  8. Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  9. Article
  10. Neurostimulation to Improve Cognitive Flexibility.Current opinion in behavioral sciences · 2025
    Article
  11. Article
  12. Review
  13. Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  14. Journal of neural engineering · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Lisa M MonteggiaDepartment of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas.
Hakon HeimerBanbury Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Eric J NestlerDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: eric.nestler@mssm.edu.
Allen Institute for Brain Science · USCold Spring Harbor Laboratory · USThe University of Texas Southwestern Medical Center · US

Funding

TRANSGENIC COREP01DA008227 · NIDA · YALE UNIVERSITY · PI NESTLER, ERIC J. · 1993 to 2018
$28.1M
REPRESSIVE HISTONE AND DNA METHYLATION IN RODENT DEPRESSION MODELSP50MH096890 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALLIS, CHARLES DAVID · 2012 to 2021
$20.2M
Using neuroeconomics to disentangle the transcriptional mechanisms underlying resilience versus susceptibility to stressR01MH051399 · NIMH · YALE UNIVERSITY · PI NESTLER, ERIC J. · 1994 to 2023
$10.2M
NIDA NIH HHS P01 DA008227NIMH NIH HHS P50 MH096890NIMH NIH HHS R01 MH051399
6 · The paper itself

Abstract

Modeling aspects of the human condition in animals has provided invaluable information on the physiology of all organ systems and has assisted in the development of virtually all new therapeutics. Research in cardiovascular disease, cancer, immunology, and other disciplines has benefited substantially from the availability of animal models that capture aspects of specific human diseases and that have been used effectively to advance new treatments. By comparison, animal models for neurological and psychiatric disorders have faced several unique obstacles. This paper highlights topics covered in a recent Cold Spring Harbor Laboratory meeting charged with examining the status of animal models for mental illness. The consensus of the conference is that despite the difficulties inherent with modeling brain disorders in animals, when used judiciously-fully cognizant that models of specific behavioral or biological aspects cannot completely recapitulate the human disorder-animal research is crucial for advancing our understanding of neuropsychiatric disease.

Indexed as

Disease Models, AnimalMental DisordersModels, GeneticNervous System DiseasesAnimalsCongresses as TopicConsensusCRISPRiPSCsNeurological disordersNonhuman primatesPsychiatric disordersRodents

Identifiers

PMID29606372
PMCPMC6269650
OpenAlexW2790249888

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.