Evidence map›Paper›PMID 29606309›Full record

ReviewTrends in cancer2018

Targeting Biophysical Cues: a Niche Approach to Study, Diagnose, and Treat Cancer.

Shirley X Zhang, Linan Liu, Weian Zhao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Cancer cell mechanobiology: a new frontier for cancer research.Journal of the National Cancer Center · 2022
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shirley X ZhangDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA; Edwards Life Sciences Center for Advanced Cardiovascular Technology, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, 845 Health Sciences Road, University of California, Irvine, Irvine, CA 92697, USA.
Linan LiuSue and Bill Gross Stem Cell Research Center, 845 Health Sciences Road, University of California, Irvine, Irvine, CA 92697, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Weian ZhaoDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA; Edwards Life Sciences Center for Advanced Cardiovascular Technology, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, 845 Health Sciences Road, University of California, Irvine, Irvine, CA 92697, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: weianz@uci.edu.

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Mechano-sensing stem cells to study, detect and treat cancer metastasesDP2CA195763 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI ZHAO, WEIAN · 2014 to 2014
$2.3M
Mechano-Sensing CAR-T Cells for Solid Tumor MetastasesR21CA219225 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI ZHAO, WEIAN · 2017 to 2018
$376k
NCATS NIH HHS UL1 TR001414NCI NIH HHS DP2 CA195763NCI NIH HHS R21 CA219225
6 · The paper itself

Abstract

Probing the biophysical properties of the tumor niche offers a new perspective in cancer mechanobiology, and supports the development of next-generation diagnostics and therapeutics for cancer, in particular for metastasis.

Indexed as

Antineoplastic AgentsBiomarkers, TumorBiophysicsElasticity Imaging TechniquesExtracellular MatrixHumansMedical OncologyNeoplasmsOncolytic VirotherapyTreatment OutcomeTumor MicroenvironmentAntineoplastic AgentsBiomarkers, Tumorbiophysical cuescancermechanobiologymetastasismicroenvironmentstem cell

Identifiers

PMID29606309
PMCPMC6226275

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.