Evidence map›Paper›PMID 29605874›Full record

ReviewInternational journal of hematology2018

The hematopoietic stem cell diet.

Adam C Wilkinson, Satoshi Yamazaki

Abstract readReview
PubMed Publisher
In one paragraph

Review in International journal of hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Article
  3. Causes of Clonal Hematopoiesis: a Review.Current oncology reports · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. In vivo and ex vivo haematopoietic stem cell expansion.Current opinion in hematology · 2020
    Review
  12. Article
  13. Analysis of Hematopoietic Stem Progenitor Cell Metabolism.Journal of visualized experiments : JoVE · 2019
    Article
  14. Review
  15. Article
  16. Metabolism as master of hematopoietic stem cell fate.International journal of hematology · 2019
    Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Adam C WilkinsonInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Lorry I. Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, CA, USA.
Satoshi YamazakiDivision of Stem Cell Therapy, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan. y-sato4@ims.u-tokyo.ac.jp.

Funding

Bloodwise 15050
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) are responsible for sustaining life-long blood formation or hematopoiesis and are also used clinically in a form of bone marrow transplantation, a curative cellular therapy for a range of hematological diseases. HSCs are maintained throughout adult life by a complex biological niche or microenvironment, which is thought to be composed of a range of cellular, molecular, and metabolic components. The metabolic components of the HSC niche have become of increasing interest over the past few years. It is now well-recognized that metabolic activity is intimately linked to HSC function, and dysregulation of these metabolic pathways result in hematological pathologies such as leukemia. Here, we review the recent progress in this field including our current understanding of the "dietary" requirements of HSCs and how nutrition influences HSC activity. These recent findings have suggested promising new metabolic approaches to improve clinical HSC transplantation and leukemia therapies.

Indexed as

Hematopoietic Stem CellsNutritional RequirementsAmino Acids, Branched-ChainBone Marrow CellsDioxygenasesDNA-Binding ProteinsHematopoietic Stem Cell TransplantationHumansLeukemiaNutritional Physiological PhenomenaProto-Oncogene ProteinsStem Cell NicheAmino Acids, Branched-ChainDioxygenasesDNA-Binding ProteinsProto-Oncogene ProteinsTET2 protein, humanHematopoietic stem cellHematopoietic stem cell transplantationHSCLeukemiaMetabolismNutrition

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.