Evidence map›Paper›PMID 29605676›Full record

ArticleEnvironment international2018

Residential proximity to major roadways and traffic in relation to outcomes of in vitro fertilization.

Audrey J Gaskins, Jaime E Hart, Lidia Mínguez-Alarcón, Jorge E Chavarro, Francine Laden, Brent A Coull, Jennifer B Ford, Irene Souter, Russ Hauser

Abstract read
In one paragraph

Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Residential Exposure to PMPaediatric and perinatal epidemiology · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Climate change, women's health, and the role of obstetricians and gynecologists in leadership.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021
    Article
  9. The effect of short term exposure to outdoor air pollution on fertility.Reproductive biology and endocrinology : RB&E · 2021
    Article
  10. Article
  11. Article
  12. Residential proximity to major roads and fecundability in a preconception cohort.Environmental epidemiology (Philadelphia, Pa.) · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Traffic-related Air Pollution and Pregnancy Loss.Epidemiology (Cambridge, Mass.) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Audrey J GaskinsDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: agaskins@hsph.harvard.edu.
Jaime E HartChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Lidia Mínguez-AlarcónDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Jorge E ChavarroDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Francine LadenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Brent A CoullDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Jennifer B FordDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Irene SouterVincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Russ HauserDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Gary Adamkiewicz · 1985 to 2026
$44.6M
PCBs, Phthalates and Male Reproductive HealthR01ES009718 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HAUSER, RUSS B · 1999 to 2018
$11.6M
Maternal and Paternal Flame Retardant Exposure, Impact on Fertility and PregnancyR01ES022955 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HAUSER, RUSS B, MEEKER, JOHN D. · 2014 to 2018
$2.9M
Maternal Exposure to Air Pollution and Early Pregnancy OutcomesK99ES026648 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI GASKINS, AUDREY JANE · 2017 to 2018
$246k
NICHD NIH HHS L50 HD085359NIEHS NIH HHS K99 ES026648NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES009718NIEHS NIH HHS R01 ES022955
6 · The paper itself

Abstract

backgroundEmerging data from animal and human studies suggest that traffic-related air pollution adversely affects early pregnancy outcomes; however evidence is limited.

objectiveWe examined whether residential proximity to major roadways and traffic, as proxies for traffic-related air pollution, are associated with in vitro fertilization (IVF) outcomes.

methodsThis analysis included 423 women enrolled in the Environment and Reproductive Health (EARTH) Study, a prospective cohort study, who underwent 726 IVF cycles (2004-2017). Using geocoded residential addresses collected at study entry, we calculated the distance to nearest major roadway and the traffic density within a 100 m radius. IVF outcomes were abstracted from electronic medical records. We used multivariable generalized linear mixed models to evaluate the associations between residential proximity to major roadways and traffic density and IVF outcomes adjusting for maternal age, body mass index, race, education level, smoking status, and census tract median income.

resultsCloser residential proximity to major roadways was statistically significantly associated with lower probability of implantation and live birth following IVF. The adjusted percentage of IVF cycles resulting in live birth for women living ≥400 m from a major roadway was 46% (95% CI 36, 56%) compared to 33% (95% CI 26, 40%) for women living <50 m (p-for-comparison, 0.04). Of the intermediate outcomes, there were suggestive associations between living closer to major roadways and slightly higher estradiol trigger concentrations (p-trend = 0.16) and lower endometrial thickness (p-trend = 0.06). Near-residence traffic density was not associated with outcomes of IVF.

conclusionCloser residential proximity to major roadways was related to reduced likelihood of live birth following IVF.

Indexed as

AutomobilesFemaleFertilization in VitroGeographic MappingHousingHumansPregnancyProspective StudiesSpatial AnalysisVehicle EmissionsVehicle EmissionsAir pollutionAssisted reproductionFertilityIn vitro fertilizationTraffic

Identifiers

PMID29605676
PMCPMC5970056

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.