ArticleMicrovascular research2018
Automated structure and flow measurement - a promising tool in nailfold capillaroscopy.
Article in Microvascular research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- A phase 2 trial investigating the effects of the angiotensin II type 2 receptor agonist C21 in systemic sclerosis-related Raynaud's.Rheumatology (Oxford, England) · 2023Trial
- Panoramic Nailfold Flow Velocity Measurement Method Based on Enhanced Plasma Gap Information.Journal of imaging informatics in medicine · 2025Article
- Article
- Nailfold videocapillaroscopic changes in patients with psoriatic arthritis: A systematic review.Biomedical reports · 2025Article
- CAPI-Detect: machine learning in capillaroscopy reveals new variables influencing diagnosis.Rheumatology (Oxford, England) · 2025Article
- Automatic assessment of nailfold capillaroscopy software: a pilot study.Reumatologia · 2024Article
- Observation and density estimation of a large number of skin capillaries using wide-field portable video capillaroscopy and semantic segmentation.Journal of biomedical optics · 2023Article
- Vision transformer assisting rheumatologists in screening for capillaroscopy changes in systemic sclerosis: an artificial intelligence model.Rheumatology (Oxford, England) · 2023Article
- A deep learning system for quantitative assessment of microvascular abnormalities in nailfold capillary images.Rheumatology (Oxford, England) · 2023Article
- Nailfold capillaroscopy: tips and challenges.Clinical rheumatology · 2022Review
- Nailfold capillary patterns correlate with age, gender, lifestyle habits, and fingertip temperature.PloS one · 2022Article
- Detection of microvascular changes in systemic sclerosis and other rheumatic diseases.Nature reviews. Rheumatology · 2021Review
- Comparison between low cost USB nailfold capillaroscopy and videocapillaroscopy: a pilot study.Rheumatology (Oxford, England) · 2021Article
- Exoscope-based videocapillaroscopy system forBiomedical optics express · 2021Article
- New perspectives in the imaging of Raynaud's phenomenon.European journal of rheumatology · 2020Review
- State-of-the-art technologies provide new insights linking skin and blood vessel abnormalities in SSc-related disorders.Microvascular research · 2020Article
- In-vivo full-field measurement of microcirculatory blood flow velocity based on intelligent object identification.Journal of biomedical optics · 2020Article
- Practical issues in assessing nailfold capillaroscopic images: a summary.Clinical rheumatology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesDespite increasing interest in nailfold capillaroscopy, objective measures of capillary structure and blood flow have been little studied. We aimed to test the hypothesis that structural measurements, capillary flow, and a combined measure have the predictive power to separate patients with systemic sclerosis (SSc) from those with primary Raynaud's phenomenon (PRP) and healthy controls (HC).
methods50 patients with SSc, 12 with PRP, and 50 HC were imaged using a novel capillaroscopy system that generates high-quality nailfold images and provides fully-automated measurements of capillary structure and blood flow (capillary density, mean width, maximum width, shape score, derangement and mean flow velocity). Population statistics summarise the differences between the three groups. Areas under ROC curves (A
resultsStatistically significant differences in group means were found between patients with SSc and both HC and patients with PRP, for all measurements, e.g. mean width (μm) ± SE: 15.0 ± 0.71, 12.7 ± 0.74 and 11.8 ± 0.23 for SSc, PRP and HC respectively. Combining the five structural measurements gave better classification (A
conclusionsStructural and blood flow measurements are both able to distinguish patients with SSc from those with PRP/HC. Importantly, these hold promise as clinical trial outcome measures for treatments aimed at improving finger blood flow or microvascular remodelling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.