ArticleJournal of the American Society of Hypertension : JASH2018
Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians.
Article in Journal of the American Society of Hypertension : JASH, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- The association between environmental cadmium exposure, blood pressure, and hypertension: a systematic review and meta-analysis.Environmental science and pollution research international · 2022Pooled it
- An updated systematic review on the association between Cd exposure, blood pressure and hypertension.Ecotoxicology and environmental safety · 2021Pooled it
- A Systematic Review of Environmental Health Outcomes in Selected American Indian and Alaska Native Populations.Journal of racial and ethnic health disparities · 2020Pooled it
- Beyond genetics: how environmental stressors drive pediatric hypertension risk.Pediatric nephrology (Berlin, Germany) · 2026Review
- Environmental Risk in American Indian Children, Including Cardiovascular and Hematologic Consequences of Cadmium Exposure: Possible Means of Mitigation.International journal of environmental research and public health · 2025Review
- Urinary βJournal of xenobiotics · 2025Article
- Antioxidative Function of Zinc and Its Protection Against the Onset and Progression of Kidney Disease Due to Cadmium.Biomolecules · 2025Review
- Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function: The Strong Heart Study.JACC. Advances · 2024Article
- An epigenome-wide study of selenium status and DNA methylation in the Strong Heart Study.Environment international · 2024Article
- Cardiotoxicity of Cadmium and Its Effects on Heart Efficiency During Early and Late Chick Embryogenesis.Cardiovascular toxicology · 2024Article
- Estimation of the Cadmium Nephrotoxicity Threshold from Loss of Glomerular Filtration Rate and Albuminuria.Toxics · 2023Article
- Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches.Toxics · 2023Review
- Evidence Linking Cadmium Exposure and βToxics · 2023Article
- Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke.Nutrients · 2023Article
- Association of multi-metals with the risk of hypertension and the interaction with obesity: A cross-sectional study in China.Frontiers in public health · 2023Article
- Epigenetic Biomarkers of Lead Exposure and Cardiovascular Disease: Prospective Evidence in the Strong Heart Study.Journal of the American Heart Association · 2022Article
- Source Identification and Health Risk Assessment of Heavy Metals in Soil: A Case Study of Lintancang Plain, Northeast China.International journal of environmental research and public health · 2022Article
- The effect of blood cadmium levels on hypertension in male firefighters in a metropolitan city.Annals of occupational and environmental medicine · 2022Article
- The Risk Factors of Blood Cadmium Elevation in Chronic Kidney Disease.International journal of environmental research and public health · 2021Article
- Urinary cadmium and stroke - a case-cohort study in Danish never-smokers.Environmental research · 2021Article
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6 authors at 3 institutions in 3 countries.
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Abstract
American Indian communities are at greater risk of hypertension and cardiovascular disease than the general US population and are exposed to greater cadmium levels. However, cadmium's effect on blood pressure is unclear. This study assesses the association between baseline urinary cadmium and longitudinal changes in blood pressure in American Indian communities. Cadmium was measured in 3047 baseline urine samples from Strong Heart Study participants from three geographic areas. Longitudinal changes in blood pressure across three study visits (1989-1999) were modeled using linear mixed models by baseline log urinary cadmium to creatinine ratio. Hypertension risk was evaluated using interval-censored survival analysis. Higher levels of urinary cadmium at baseline were associated with faster rates of increase in diastolic and systolic blood pressure (P [trend] = .001 and .02, respectively). The estimated change in diastolic and systolic blood pressures per year was 0.18 mm Hg (0.05-0.31) and 0.62 mm Hg (0.37-0.87) in the upper quintile of cadmium level compared with -0.11 mm Hg (-0.24 to 0.02) and 0.21 mm Hg (-0.04 to 0.46) in the lowest, respectively. A one-unit increase in log-transformed urinary cadmium was associated with 10% greater hypertension risk (95% confidence interval: 1.01-1.20). In conclusion, blood pressure of individuals with greater baseline levels of urinary cadmium increased at a faster rate relative to those with lower levels.
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