Evidence map›Paper›PMID 29605222›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2018

Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease.

Jennifer L Whitwell, Jonathan Graff-Radford, Nirubol Tosakulwong, Stephen D Weigand, Mary M Machulda, Matthew L Senjem, Anthony J Spychalla, Prashanthi Vemuri, David T Jones, Daniel A Drubach and 7 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 113 citations in OpenAlex.

  1. Article
  2. Network-dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Review
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  6. Article
  7. Article
  8. Nuclear medicine and molecular imaging · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Heterogeneous tau deposition patterns in the preclinical stage link to domain-specific cognitive deficits.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  14. Article
  15. Article
  16. Baseline multimodal imaging to predict longitudinal clinical decline in atypical Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2024
    Article
  17. Review
  18. Article
  19. Review
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: whitwell.jennifer@mayo.edu.
Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Nirubol TosakulwongDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Stephen D WeigandDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Mary M MachuldaDepartment of Psychology and Psychiatry, Mayo Clinic, Rochester, MN, USA.
Matthew L SenjemDepartment of Radiology, Mayo Clinic, Rochester, MN, USA; Department of Information Technology, Mayo Clinic, Rochester, MN, USA.
Anthony J SpychallaDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Prashanthi VemuriDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
David T JonesDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Daniel A DrubachDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Nilüfer Ertekin-TanerDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Arizona · USMayo Clinic in Florida · USJacksonville College · USWinnMed · US

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 1999 to 2018
$36.9M
Integrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, PETERS, METTE · 2013 to 2022
$24.6M
PREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1M
Integrative translational discovery of vascular risk factors in aging and dementiaRF1AG051504 · NIA · MAYO CLINIC JACKSONVILLE · PI BU, GUOJUN, ERTEKIN-TANER, NILUFER · 2015 to 2019
$9.8M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
Molecular and structural imaging in atypical Alzheimer's disease: a longitudinal studyR01AG050603 · NIA · MAYO CLINIC ROCHESTER · PI WHITWELL, JENNIFER LOUISE · 2016 to 2025
$5.9M
Gene discovery in PSP by transcriptome, neuropathology and sequence analysisR01NS080820 · NINDS · MAYO CLINIC JACKSONVILLE · PI ERTEKIN-TANER, NILUFER · 2013 to 2017
$1.8M
Assessment of hyperphosphorylated tau PET binding in primary progressive aphasiaR21NS094684 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2016 to 2017
$417k
NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG011378NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG050603NIA NIH HHS RF1 AG051504NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG046139NINDS NIH HHS R01 NS080820NINDS NIH HHS R21 NS094684
6 · The paper itself

Abstract

introductionNeuroimaging modalities can measure different aspects of the disease process in Alzheimer's disease, although the relationship between these modalities is unclear.

methodsWe assessed subject-level regional correlations between tau on [

results[ DISCUSSION: These findings support a close relationship between tau and hypometabolism in Alzheimer's disease but show that correlations between neuroimaging modalities vary across participants.

Indexed as

AgedAlzheimer DiseaseAmyloidogenic ProteinsAtrophyBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingNeuropsychological TestsPositron-Emission TomographyRadiopharmaceuticalstau ProteinsAmyloidogenic ProteinsRadiopharmaceuticalstau ProteinsAlzheimer's diseaseCortical thicknessLogopenic aphasiaMagnetic resonance imagingPositron emission tomographyPosterior cortical atrophyTauβ amyloid

Identifiers

PMID29605222
PMCPMC6097955
OpenAlexW2794753783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.