Evidence map›Paper›PMID 29604885›Full record

ArticleThe Journal of chemical physics2018

Improved free-energy landscape reconstruction of bacteriorhodopsin highlights local variations in unfolding energy.

Patrick R Heenan, Hao Yu, Matthew G W Siewny, Thomas T Perkins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of chemical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Quantifying a light-induced energetic change in bacteriorhodopsin by force spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Untangling the complexity of membrane protein folding.Current opinion in structural biology · 2022
    Review
  5. Free-energy changes of bacteriorhodopsin point mutants measured by single-molecule force spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  6. Modulation of a protein-folding landscape revealed by AFM-based force spectroscopy notwithstanding instrumental limitations.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Patrick R HeenanJILA, National Institute of Standard and Technology and University of Colorado, Boulder, Colorado 80309, USA.ORCID 0000000217200055
Hao YuJILA, National Institute of Standard and Technology and University of Colorado, Boulder, Colorado 80309, USA.
Matthew G W SiewnyJILA, National Institute of Standard and Technology and University of Colorado, Boulder, Colorado 80309, USA.
Thomas T PerkinsJILA, National Institute of Standard and Technology and University of Colorado, Boulder, Colorado 80309, USA.ORCID 0000000348269490
University of Colorado Boulder · US

Funding

Predoctoral Training Molecular BiophysicsT32GM065103 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 2002 to 2021
$4.3M
NIGMS NIH HHS T32 GM065103
6 · The paper itself

Abstract

Precisely quantifying the energetics that drive the folding of membrane proteins into a lipid bilayer remains challenging. More than 15 years ago, atomic force microscopy (AFM) emerged as a powerful tool to mechanically extract individual membrane proteins from a lipid bilayer. Concurrently, fluctuation theorems, such as the Jarzynski equality, were applied to deduce equilibrium free energies (ΔG

Indexed as

ThermodynamicsBacteriorhodopsinsLipid BilayersMicroscopy, Atomic ForceProtein FoldingBacteriorhodopsinsLipid Bilayers

Identifiers

PMID29604885
PMCPMC6910583
OpenAlexW2779530513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.