ArticleNeuroscience2018
Inactivation of the Ventrolateral Orbitofrontal Cortex Impairs Flexible Use of Safety Signals.
Article in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- Insular input to the prelimbic cortex underlies social affective behavior in rats.bioRxiv : the preprint server for biology · 2025Article
- Neurobehavioral mechanisms of fear and anxiety in multiple sclerosis.Communications medicine · 2025Article
- Age and sex independently influence safety learning in mice.Behavioural brain research · 2025Article
- Pavlovian safety learning: An integrative theoretical review.Psychonomic bulletin & review · 2025Review
- Orbitofrontal and Prelimbic Cortices Serve Complementary Roles in Adapting Reward Seeking to Learned Anxiety.Biological psychiatry · 2024Article
- Orbitofrontal cortex modulates auditory cortical sensitivity and sound perception in Mongolian gerbils.Current biology : CB · 2024Article
- Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease.Behavioral neuroscience · 2024Review
- The ventromedial prefrontal cortex in response to threat omission is associated with subsequent explicit safety memory.Scientific reports · 2024Article
- NrCAM-deficient mice exposed to chronic stress exhibit disrupted latent inhibition, a hallmark of schizophrenia.Frontiers in behavioral neuroscience · 2024Article
- Brain-Derived Neurotrophic Factor Val66Met Genotype Modulates Latent Inhibition: Relevance for Schizophrenia.Schizophrenia bulletin · 2023Article
- Social affective behaviors among female rats involve the basolateral amygdala and insular cortex.bioRxiv : the preprint server for biology · 2023Article
- Social affective behaviors among female rats involve the basolateral amygdala and insular cortex.PloS one · 2023Article
- Measuring human trace fear conditioning.Psychophysiology · 2022Article
- Cortico-Striatal Activity Characterizes Human Safety Learning via Pavlovian Conditioned Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Environmental certainty influences the neural systems regulating responses to threat and stress.Neuroscience and biobehavioral reviews · 2021Review
- Psychosocial impairment following mild blast-induced traumatic brain injury in rats.Behavioural brain research · 2021Article
- Retrorubral field is a hub for diverse threat and aversive outcome signals.Current biology : CB · 2021Article
- Pre-adolescent stress disrupts adult, but not adolescent, safety learning.Behavioural brain research · 2021Article
- Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain.The American journal of psychiatry · 2021Review
- Absence Makes the Mind Grow Fonder: Reconceptualizing Studies of Safety Learning in Translational Research on Anxiety.Cognitive, affective & behavioral neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Survival depends on adaptation to shifting environmental risks and opportunities. Regarding risks, the mechanisms which permit acquisition, recall, and flexible use of aversive associations is poorly understood. Drawing on the evidence that the orbital frontal cortex is critical to integrating outcome expectancies with flexible appetitive behavioral responses, we hypothesized that OFC would contribute to behavioral flexibility within an aversive learning domain. We introduce a fear conditioning procedure in which adult male rats were presented with shock-paired conditioned stimulus (CS+) or a safety cue (CS-). In a recall test, rats exhibit greater freezing to the CS+ than the CS-. Temporary inactivation of the ventrolateral OFC with muscimol prior to conditioning did not affect later discrimination, but inactivation after learning and prior to recall impaired discrimination between safety and danger cues. This result complements prior research in the appetitive domain and suggests that the OFC plays a general role in behavioral flexibility regardless of the valence of the CS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.