Evidence map›Paper›PMID 29604295›Full record

Trial reportNeuropharmacology2018

Cannabinoid receptor-mediated disruption of sensory gating and neural oscillations: A translational study in rats and humans.

Patrick D Skosnik, Mihály Hajós, Jose A Cortes-Briones, Chad R Edwards, Brian P Pittman, William E Hoffmann, Andrew R Sewell, Deepak C D'Souza, Mohini Ranganathan

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
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  7. Article
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  14. Article
  15. Aberrant inhibitory processing in the somatosensory cortices of cannabis-users.Journal of psychopharmacology (Oxford, England) · 2021
    Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Patrick D SkosnikDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: patrick.skosnik@yale.edu.
Mihály HajósDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
Jose A Cortes-BrionesDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Chad R EdwardsDevelopmental Neuropsychological Services, P.C., South Bend, IN 46615, USA.
Brian P PittmanDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
William E HoffmannDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
Andrew R SewellDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Deepak C D'SouzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Mohini RanganathanDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Yale University · US

Funding

Cannabidiol Modulation of ???-9-THC???s Psychotomimetic Effects in Healthy HumansR21DA030696 · NIDA · YALE UNIVERSITY · PI D'SOUZA, DEEPAK CYRIL, RANGANATHAN, MOHINI · 2011 to 2012
$360k
NIDA NIH HHS R21 DA030696
6 · The paper itself

Abstract

Cannabis use has been associated with altered sensory gating and neural oscillations. However, it is unclear which constituent in cannabis is responsible for these effects, or whether these are cannabinoid receptor 1 (CB1R) mediated. Therefore, the present study in humans and rats examined whether cannabinoid administration would disrupt sensory gating and evoked oscillations utilizing electroencephalography (EEG) and local field potentials (LFPs), respectively. Human subjects (n = 15) completed four test days during which they received intravenous delta-9-tetrahydrocannabinol (Δ

Indexed as

AdultAnimalsBrainBrain WavesCannabinoid Receptor ModulatorsCyclohexanolsDouble-Blind MethodDronabinolFemaleHumansMalePiperidinesPyrazolesRats, Sprague-DawleyReceptor, Cannabinoid, CB1Sensory Gating3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanolAM 251Cannabinoid Receptor ModulatorsCNR1 protein, humanCnr1 protein, ratCyclohexanolsDronabinolPiperidinesPyrazolesReceptor, Cannabinoid, CB1CannabinoidEEGNeural oscillationsP50Sensory gatingTheta

Identifiers

PMID29604295
PMCPMC6091633
OpenAlexW2795218432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.