Evidence map›Paper›PMID 29604251›Full record

Observational studyThe Journal of investigative dermatology2018

Patients with Atopic Dermatitis Colonized with Staphylococcus aureus Have a Distinct Phenotype and Endotype.

Eric L Simpson, Miguel Villarreal, Brett Jepson, Nick Rafaels, Gloria David, Jon Hanifin, Patricia Taylor, Mark Boguniewicz, Takeshi Yoshida, Anna De Benedetto and 3 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in The Journal of investigative dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Review
  10. Article
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  14. Review
  15. Atopic Dermatitis-like mouse model using early inoculation of patient-derivedJID innovations : skin science from molecules to population health · 2026
    Article
  16. Basophils in atopic dermatitis: Immunologic roles and clinical implications.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Review
  17. Article
  18. Review
  19. Article
  20. The Mechanisms of Immunoglobulin E Sensitizations in Atopic Dermatitis.Immunology and allergy clinics of North America · 2025
    Review

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eric L SimpsonOregon Health & Science University, Portland, Oregon, USA.
Miguel VillarrealRho, Inc., Chapel Hill, North Carolina, USA.
Brett JepsonRho, Inc., Chapel Hill, North Carolina, USA.
Nick RafaelsUniversity of Colorado, Boulder, Colorado, USA.
Gloria DavidRho, Inc., Chapel Hill, North Carolina, USA.
Jon HanifinOregon Health & Science University, Portland, Oregon, USA.
Patricia TaylorNational Jewish Health, Denver, Colorado, USA.
Mark BoguniewiczNational Jewish Health, Denver, Colorado, USA.
Takeshi YoshidaUniversity of Rochester Medical Center, Rochester, New York, USA.
Anna De BenedettoUniversity of Rochester Medical Center, Rochester, New York, USA.
Kathleen C BarnesUniversity of Colorado, Boulder, Colorado, USA.
Donald Y M LeungNational Jewish Health, Denver, Colorado, USA.
Lisa A BeckUniversity of Rochester Medical Center, Rochester, New York, USA. Electronic address: lisa_beck@urmc.rochester.edu.

Funding

Transplantation GroupUM2AI117870 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI DAVID, GLORIA · 2015 to 2023
$208.1M
Targeted Microbiome Transplant in Atopic DermatitisU19AI117673 · NIAID · NATIONAL JEWISH HEALTH · PI LEUNG, DONALD YM · 2015 to 2019
$30.6M
SEAL (Stopping Atopic dermatitis and ALlergy) Study: Prevent allergy by enhancing the skin barrierU01AI147462 · NIAID · STANFORD UNIVERSITY · PI Mary Johnson, GIDEON LACK · 2020 to 2026
$14.0M
Biomarker Identification, Viral Susceptibility and Management in S. aureus Colonized AD PatientsU01AI152011 · NIAID · UNIVERSITY OF ROCHESTER · PI Lisa Ann Beck · 2020 to 2026
$3.2M
Effect of the PPAR Agonist Pioglitazone on Epidermal Barrier in Atopic DermatitisR21AR062357 · NIAMS · UNIVERSITY OF ROCHESTER · PI BECK, LISA ANN · 2012 to 2014
$380k
NIAID NIH HHS U01 AI147462NIAID NIH HHS U01 AI152011NIAID NIH HHS U19 AI117673NIAID NIH HHS UM2 AI117870NIAMS NIH HHS R21 AR062357
6 · The paper itself

Abstract

Patients with atopic dermatitis (AD) are commonly colonized with Staphylococcus aureus (AD S. aureus

Indexed as

AdolescentAdultBiomarkersColony Count, MicrobialCross-Sectional StudiesDermatitis, AtopicFemaleFilaggrin ProteinsGenotypeHumansIntermediate Filament ProteinsMaleMiddle AgedPhenotypeSeverity of Illness IndexStaphylococcal Skin InfectionsBiomarkersFilaggrin ProteinsFLG protein, humanIntermediate Filament Proteins

Identifiers

PMID29604251
PMCPMC6153055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.