Evidence map›Paper›PMID 29604178›Full record

ArticleThe FEBS journal2018

Cysteine dioxygenase is essential for mouse sperm osmoadaptation and male fertility.

Atsushi Asano, Heather B Roman, Lawrence L Hirschberger, Ai Ushiyama, Jacquelyn L Nelson, Meleana M Hinchman, Martha H Stipanuk, Alexander J Travis

Open access · greenAbstract read
In one paragraph

Article in The FEBS journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Atsushi AsanoFaculty of Life and Environmental Sciences, University of Tsukuba, Japan.
Heather B RomanDepartment of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Lawrence L HirschbergerDepartment of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Ai UshiyamaGraduate School of Life and Environmental Sciences, University of Tsukuba, Japan.
Jacquelyn L NelsonThe Baker Institute for Animal Health, Cornell University, Ithaca, NY, USA.
Meleana M HinchmanThe Baker Institute for Animal Health, Cornell University, Ithaca, NY, USA.
Martha H StipanukDepartment of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Alexander J TravisThe Baker Institute for Animal Health, Cornell University, Ithaca, NY, USA.
Cornell University · USUniversity of Tsukuba · JP

Funding

NUTRITIONAL REGULATION OF CYSTEINE DIOXYGENASER01DK056649 · NIDDK · CORNELL UNIVERSITY ITHACA · PI STIPANUK, MARTHA H · 2000 to 2013
$4.0M
Nanoscale energy production for implantable medical devicesDP1OD006431 · OD · CORNELL UNIVERSITY · PI TRAVIS, ALEXANDER J · 2009 to 2011
$2.3M
NIDDK NIH HHS R01 DK056649NIH HHS DP1 OD006431
6 · The paper itself

Abstract

Sperm entering the epididymis are immotile and cannot respond to stimuli that will enable them to fertilize. The epididymis is a highly complex organ, with multiple histological zones and cell types that together change the composition and functional abilities of sperm through poorly understood mechanisms. Sperm take up taurine during epididymal transit, which may play antioxidant or osmoregulatory roles. Cysteine dioxygenase (CDO) is a critical enzyme for taurine synthesis. A previous study reported that male CDO

Indexed as

FertilityOsmoregulationAcrosome ReactionAnimalsAntioxidantsBlotting, WesternChromatography, High Pressure LiquidCysteine DioxygenaseEpididymisExocytosisFemaleLipid PeroxidationMaleMiceMice, KnockoutPhosphorylationAntioxidantsCysteine DioxygenasehypotaurineRNA, MessengerTaurineepididymal maturationfertilizationspermtaurine

Identifiers

PMID29604178
PMCPMC5992081
OpenAlexW2794626098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.