ArticlePlant biotechnology journal2018
Genome and evolution of the shade-requiring medicinal herb Panax ginseng.
Article in Plant biotechnology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 219 citations in OpenAlex.
- Chromosome-level genome of wild-simulated Panax ginseng identifies SNP markers for germplasm and medicinal quality evaluation.Journal of advanced research · 2026Article
- Comprehensive Identification and Integrated Analysis of theLife (Basel, Switzerland) · 2026Article
- Integration of Transcriptomics and Metabolomics Reveals Organ-Specific Biosynthesis and Accumulation of Pharmacologically Active Flavonoids inPlants (Basel, Switzerland) · 2026Article
- Comprehensive Identification ofBiology · 2026Article
- Cytogenomic profiling ofJournal of ginseng research · 2026Article
- A cross-cultural ethnobotanical assembly highlights diverse health-promoting functions of genusChinese herbal medicines · 2026Article
- Comprehensive analysis of the pan-plastome in Panax: implications for interspecies divergence and shade tolerance.BMC plant biology · 2026Article
- From folklore to explore: integrating genomic and multiomics data forHorticulture research · 2026Article
- Therapeutic effect of ginseng: a non-antibiotic approach to preventing pathogenic bacterial infections and restoring gut microbiota composition.Frontiers in pharmacology · 2026Review
- Genome-wide and co-expression network dissection ofFrontiers in plant science · 2026Article
- Mechanistic Perspectives From Genomics and Pangenomics of Medicinal and Aromatic Plants: Linking Genome Architecture to Phytochemical Diversity.International journal of genomics · 2026Review
- Comparative mitochondrial genome analysis of Panax ginseng reveals structural variation and genetic diversity.Scientific reports · 2025Article
- Genome-wide identification and analysis of YTH gene family and its response to MeJA and salt treatment in Panax ginseng C. A. Meyer.BMC plant biology · 2025Article
- Functional Study ofPlants (Basel, Switzerland) · 2025Article
- Integrated single-cell transcriptomics and spatial metabolomics unveil cellular differentiation and ginsenosides biosynthesis inHorticulture research · 2025Article
- Conservation and Remodeling of Alternative Splicing Landscapes in the Evolution ofPlants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification of the AP2/ERF Gene Family and Functional Analysis ofPlants (Basel, Switzerland) · 2025Article
- Root-Zone Temperature Drives Coordinated Photosynthesis, Root Architecture, and Metabolism Responses inPlants (Basel, Switzerland) · 2025Article
- Transcriptome Analysis of Developmental Gene Expression inPlants (Basel, Switzerland) · 2025Article
- Transcriptome-wide identification and systematic analysis of the Retrotransposon genes and their roles in ginsenoside biosynthesis in Panax ginseng.BMC plant biology · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors at 15 institutions in 6 countries.
Funding
Abstract
Panax ginseng C. A. Meyer, reputed as the king of medicinal herbs, has slow growth, long generation time, low seed production and complicated genome structure that hamper its study. Here, we unveil the genomic architecture of tetraploid P. ginseng by de novo genome assembly, representing 2.98 Gbp with 59 352 annotated genes. Resequencing data indicated that diploid Panax species diverged in association with global warming in Southern Asia, and two North American species evolved via two intercontinental migrations. Two whole genome duplications (WGD) occurred in the family Araliaceae (including Panax) after divergence with the Apiaceae, the more recent one contributing to the ability of P. ginseng to overwinter, enabling it to spread broadly through the Northern Hemisphere. Functional and evolutionary analyses suggest that production of pharmacologically important dammarane-type ginsenosides originated in Panax and are produced largely in shoot tissues and transported to roots; that newly evolved P. ginseng fatty acid desaturases increase freezing tolerance; and that unprecedented retention of chlorophyll a/b binding protein genes enables efficient photosynthesis under low light. A genome-scale metabolic network provides a holistic view of Panax ginsenoside biosynthesis. This study provides valuable resources for improving medicinal values of ginseng either through genomics-assisted breeding or metabolic engineering.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.