ArticleThe Journal of physiology2018
Moderate and severe hypoxia elicit divergent effects on cardiovascular function and physiological rhythms.
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Physiological Responses to High-Intensity Interval Exercise in Hypoxia Among Lean Males and Those With Overweight or Obesity.European journal of sport science · 2025Trial
- High-Altitude Pilot Physiological Monitoring Dataset: Respiratory Performance and SpO₂ Analysis.Scientific data · 2026Article
- Twenty-Four Hour Rhythms in Cardiovascular Physiology.Acta physiologica (Oxford, England) · 2025Review
- Dose-effect of exercise intervention on heart rate variability of acclimatized young male lowlanders at 3,680 m.Frontiers in physiology · 2024Article
- Hypoxia-induced inflammation: Profiling the first 24-hour posthypoxic plasma and central nervous system changes.PloS one · 2021Article
- Applications of a novel radiotelemetry method for the measurement of intrathoracic pressures and physiological rhythms in freely behaving mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Hemodynamic assessment of diastolic function for experimental models.American journal of physiology. Heart and circulatory physiology · 2020Review
- Disruption of Physiological Rhythms Persist Following Cessation of Cigarette Smoke Exposure in Mice.Frontiers in physiology · 2020Article
- Melatonin alleviates hypoxia-induced cardiac apoptosis through PI3K/Akt pathway.International journal of clinical and experimental pathology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
key pointsIn the present study, we provide evidence for divergent physiological responses to moderate compared to severe hypoxia, addressing an important knowledge gap related to severity, duration and after-effects of hypoxia encountered in cardiopulmonary situations. The physiological responses to moderate and severe hypoxia were not proportional, linear or concurrent with the time-of-day. Hypoxia elicited severity-dependent physiological responses that either persisted or fluctuated throughout normoxic recovery. The physiological basis for these distinct cardiovascular responses implicates a shift in the sympathovagal set point and probably not molecular changes at the artery resulting from hypoxic stress. ABSTRACT: Hypoxia is both a consequence and cause of many acute and chronic diseases. Severe hypoxia causes hypertension with cardiovascular sequelae; however, the rare studies using moderate severities of hypoxia indicate that it can be beneficial, suggesting that hypoxia may not always be detrimental. Comparisons between studies are difficult because of the varied classifications of hypoxic severities, methods of delivery and use of anaesthetics. Thus, to investigate the long-term effects of moderate hypoxia on cardiovascular health, radiotelemetry was used to obtain in vivo physiological measurements in unanaesthetized mice during 24 h of either moderate
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.