Evidence map›Paper›PMID 29603563›Full record

ArticleAngewandte Chemie (International ed. in English)2018

Palaeoproteomic Profiling of Conservation Layers on a 14th Century Italian Wall Painting.

Meaghan Mackie, Patrick Rüther, Diana Samodova, Fabiana Di Gianvincenzo, Clara Granzotto, David Lyon, David A Peggie, Helen Howard, Lynne Harrison, Lars Juhl Jensen and 2 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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  6. The Japanese Archipelago sheltered cave lions, not tigers, during the Late Pleistocene.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  18. Threatened North African seagrass meadows have supported green turtle populations for millennia.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Meaghan MackieNatural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350, Copenhagen, Denmark.ORCID 0000-0003-0763-7592
Patrick RütherProteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark.ORCID 0000-0003-4461-9828
Diana SamodovaProteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark.ORCID 0000-0001-9943-931X
Fabiana Di GianvincenzoNatural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350, Copenhagen, Denmark.ORCID 0000-0003-3304-0749
Clara GranzottoNatural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350, Copenhagen, Denmark.ORCID 0000-0002-7839-4316
David LyonDisease Systems Biology Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark.ORCID 0000-0001-5794-0456
David A PeggieScientific Department, National Gallery London, Trafalgar Square, London, WC2N 5DN, UK.ORCID 0000-0003-2757-3207
Helen HowardScientific Department, National Gallery London, Trafalgar Square, London, WC2N 5DN, UK.
Lynne HarrisonConservation Department, National Gallery London, Trafalgar Square, London, WC2N 5DN, UK.
Lars Juhl JensenDisease Systems Biology Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark.ORCID 0000-0001-7885-715X
Jesper V OlsenProteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark.ORCID 0000-0002-4747-4938
Enrico CappelliniNatural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350, Copenhagen, Denmark.ORCID 0000-0001-7885-7811

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ahead of display, a non-original layer was observed on the surface of a fragment of a wall painting by Ambrogio Lorenzetti (active 1319, died 1348/9). FTIR analysis suggested proteinaceous content. Mass spectrometry was used to better characterise this layer and revealed two protein components: sheep and cow glue and chicken and duck egg white. Analysis of post-translational modifications detected several photo-oxidation products, which suggest that the egg experienced prolonged exposure to UV light and was likely applied long before the glue layer. Additionally, glycation products detected may indicate naturally occurring glycoprotein degradation or reaction with a carbohydrate material such as starch, identified by ATR-FTIR in a cross-section of a sample taken from the painting. Palaeoproteomics is shown to provide detailed characterisation of organic layers associated with mural paintings and therefore aids reconstruction of the conservation history of these objects.

Indexed as

conservation sciencecultural heritagemass spectrometrypost-translational modificationsproteomics

Identifiers

PMID29603563
PMCPMC6032867

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.