ArticleMolecular plant pathology2018
Plant and animal PR1 family members inhibit programmed cell death and suppress bacterial pathogens in plant tissues.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 86 citations in OpenAlex.
- A PR1-Like Protein Stabilizes a Barwin-Like Protein to Enhance Wheat Resistance to Leaf Rust.Plant, cell & environment · 2026Article
- Biochar mitigates Fusarium wilt by regulating the rhizosphere microbial community structure.Pest management science · 2026Article
- Spatial organization of plant defense at the infection front.bioRxiv : the preprint server for biology · 2026Article
- Genome-wide identification of AP2/ERF transcription factors in Populus trichocarpa: structural analysis, expression patterns, and response to Melampsora larici-populina.BMC plant biology · 2026Article
- Genome-Wide Identification and Expression Analysis of Pathogenesis-Related Protein 1 in Sweet Potato and Its Two Relatives.Food science & nutrition · 2026Article
- Selected cell wall-associated components in plant defense responses against microbial pathogens.Frontiers in plant science · 2026Review
- The CAPE1 peptide confers resistance against bacterial wilt in tomato.Journal of experimental botany · 2025Article
- Metabolomic Profiling Identifies Key Metabolites and Defense Pathways inInternational journal of molecular sciences · 2025Article
- Re-Examination Characterization and Screening of Stripe Rust Resistance Gene of WheatInternational journal of molecular sciences · 2025Article
- Systematic expression analysis of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 protein (CAP) superfamily inPlant direct · 2024Article
- Efficient enhancement of the antimicrobial activity of Chlamydomonas reinhardtii extract by transgene expression and molecular modification using ionizing radiation.Biotechnology for biofuels and bioproducts · 2024Article
- Mining of disease-resistance genes inFrontiers in genetics · 2024Article
- Small secreted proteins and exocytosis regulators: do they go along?Plant signaling & behavior · 2023Article
- The function of plant PR1 and other members of the CAP protein superfamily in plant-pathogen interactions.Molecular plant pathology · 2023Review
- Genome-Wide Identification and Expression Profiling of Pathogenesis-Related Protein 1 (Plants (Basel, Switzerland) · 2023Article
- Article
- Goss's Wilt Resistance in Corn Is Mediated via Salicylic Acid and Programmed Cell Death but Not Jasmonic Acid Pathways.Plants (Basel, Switzerland) · 2023Article
- Characterization and functional analyses of wheat TaPR1 genes in response to stripe rust fungal infection.Scientific reports · 2023Article
- Pathogenesis-related protein 1 suppresses oomycete pathogen by targeting against AMPK kinase complex.Journal of advanced research · 2023Article
- Mutation ofInternational journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A role for programmed cell death (PCD) has been established as the basis for plant-microbe interactions. A functional plant-based cDNA library screen identified possible anti-PCD genes, including one member of the PR1 family, designated P14a, from tomato. Members of the PR1 family have been subject to extensive research in view of their possible role in resistance against pathogens. The PR1 family is represented in every plant species studied to date and homologues have been found in animals, fungi and insects. However, the biological function of the PR1 protein from plants has remained elusive in spite of extensive research regarding a role in the response of plants to disease. Constitutive expression of P14a in transgenic tomato roots protected the roots against PCD triggered by Fumonisin B1, as did the human orthologue GLIPR1, indicating a kingdom crossing function for PR1. Tobacco plants transformed with a P14a-GFP fusion construct and inoculated with Pseudomonas syringae pv. tabaci revealed that the mRNA was abundant throughout the leaves, but the fusion protein was restricted to the lesion margins, where cell death and bacterial spread were arrested. Vitus vinifera grapes expressing the PR1 homologue P14a as a transgene were protected against the cell death symptoms of Pierce's disease. A pull-down assay identified putative PR1-interacting proteins, including members of the Rac1 immune complex, known to function in innate immunity in rice and animal systems. The findings herein are consistent with a role of PR1 in the suppression of cell death-dependent disease symptoms and a possible mode of action.
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