ArticleAngewandte Chemie (International ed. in English)2018
Tunable Pentapeptide Self-Assembled β-Sheet Hydrogels.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Experimental and Computational Study of Injectable Iron(III)/Ultrashort Peptide Hydrogels: A Candidate for Ferroptosis-Induced Treatment of Bacterial Infections.Small science · 2025Article
- Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo.bioRxiv : the preprint server for biology · 2025Article
- Scrambled RGD Hexameric Peptide Hydrogel Supports Efficient Self-Assembly and Cell Activity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Phenylalanine-Based Amphiphilic Self-Assembled Materials: Gels or Crystals?Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- RGD-functionalised self-assembling peptide hydrogel induces a proliferative profile in human osteoblasts in vitro.Journal of peptide science : an official publication of the European Peptide Society · 2025Article
- Influence of Electrostatic Interactions on the Self-Assembly of Charged Peptides.Gels (Basel, Switzerland) · 2025Article
- Self-assembling peptides for sciatic nerve regeneration: a review of conduit microenvironment modeling strategies in preclinical studies.Frontiers in cell and developmental biology · 2025Review
- A thermo-sensitive peptide hydrogel loaded with paclitaxel and antimony nanosheets for synergistic photothermal-chemotherapeutic treatment of breast cancer.Frontiers in pharmacology · 2025Article
- Visualizing nanostructures in supramolecular hydrogels: a correlative study using confocal and cryogenic scanning electron microscopy.Beilstein journal of nanotechnology · 2025Article
- Molecular-Level Design Principles and Strategies of Peptide Self-Assembly Nanomaterials: From Sequence Engineering to Functional Applications.International journal of nanomedicine · 2025Review
- Recent research of peptide-based hydrogel in nervous regeneration.Bioactive materials · 2024Review
- Elastin-Derived Peptide-Based Hydrogels as a Potential Drug Delivery System.Gels (Basel, Switzerland) · 2024Article
- In Situ Synthesis and Self-Assembly of Peptide-PEG Conjugates: A Facile Method for the Construction of Fibrous Hydrogels.Biomacromolecules · 2024Article
- Biostable hydrogels consisting of hybrid β-sheet fibrils assembled by a pair of enantiomeric peptides.Materials today. Bio · 2024Article
- Peptide-Based Hydrogels: Template Materials for Tissue Engineering.Journal of functional biomaterials · 2023Review
- Emerging 3D bioprinting applications in plastic surgery.Biomaterials research · 2023Review
- Insight into the self-assembly and gel formation of a bioactive peptide derived from bovine casein.BBA advances · 2023Article
- Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications.Materials (Basel, Switzerland) · 2022Review
- Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oligopeptide-based supramolecular hydrogels hold promise in a range of applications. The gelation of these systems is hard to control, with minor alterations in the peptide sequence significantly influencing the self-assembly process. We explored three pentapeptide sequences with different charge distributions and discovered that they formed robust, pH-responsive hydrogels. By altering the concentration and charge distribution of the peptide sequence, the stiffness of the hydrogels could be tuned across two orders of magnitude (2-200 kPa). Also, through reassembly of the β-sheet interactions the hydrogels could self-heal and they demonstrated shear-thin behavior. Using spectroscopic and cryo-imaging techniques, we investigated the relationship between peptide sequence and molecular structure, and how these influence the mechanical properties of the hydrogel. These pentapeptide hydrogels with tunable morphology and mechanical properties have promise in tissue engineering, injectable delivery vectors, and 3D printing applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.